| Barrett's食管组织中环氧合酶-2的表达及食管动力学测定 |
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| 引用本文： | 王瑞华,欧阳钦,魏兵,常玉英,李国栋,向军英. Barrett's食管组织中环氧合酶-2的表达及食管动力学测定[J]. 郑州大学学报(医学版), 2006, 41(5) |
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| 作者姓名： | 王瑞华 欧阳钦 魏兵 常玉英 李国栋 向军英 |
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| 作者单位： | 1. 四川大学华西医院消化科,成都,610041
2. 四川大学华西医院病理科,成都,610041 |
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| 摘 要： | 目的:探讨Barrett's食管(BE)食管运动功能、环氧合酶-2(COX-2)的表达及其发病机制。方法:收集62例经内镜和病理确诊的BE患者的资料,对其中21例的食管动力学检查结果进行分析;采用免疫组化SP法检测其中37例食管黏膜组织中COX-2蛋白的表达。以20例同期健康体检者和23例反流性食管炎(RE)患者作对照。结果:BE组下食管括约肌(LES)压力低于RE组及健康对照组,BE组食管远端收缩波幅较RE组及对照组降低(P均<0.05),而食管近端收缩波幅3组间差异无统计学意义(P>0.05)。正常十二指肠上皮组织中COX-2无表达,而20/24无不典型增生BE肠化黏膜、12/13不典型增生BE肠化黏膜表达COX-2蛋白,且2者间表达差异无统计学意义(P<0.05)。结论:LES功能失调是BE主要发病机制,COX-2蛋白的表达是BE发生的早期事件。
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| 关 键 词： | Barrett's食管 食管运动功能 下食管括约肌压力 环氧合酶-2 |
Expression of COX-2 in Barrett's esophageal tissue and esophagus motor function |
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| WANG Ruihua,OUYANG Qin,WEI Bing,CHANG Yuying,LI Guodong,XIANG Junying. Expression of COX-2 in Barrett's esophageal tissue and esophagus motor function[J]. Journal of Zhengzhou University: Med Sci, 2006, 41(5) |
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| Authors: | WANG Ruihua OUYANG Qin WEI Bing CHANG Yuying LI Guodong XIANG Junying |
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| Affiliation: | WANG Ruihua 1),OUYANG Qin 1),WEI Bing 2),CHANG Yuying 1),LI Guodong 1),XIANG Junying 1) 1)Department of Gastroenterology,West China Hospital,Sichuan University,Chengdu 610041 2)Department of Pathology,West China Hospital,Sichuan University,Chengdu 610041 |
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| Abstract: | Aim: To investigate the expression of cyclooxygenase-2 (COX-2)and motor function of Barrett's esophagus(BE).Methods: The clinical characteristics of sixty-two BE patients were analyzed, Motor function of esophagus was detected in 21 cases,and the expression of COX-2 in mucosa were detected in 37 cases. Twenty healthy individuals and 23 patients with reflux esophagitis (RE) were the control.Results: Lower esophageal sphincter (LES)pressure and distal esophageal contraction amplitude of BE patients were lower than those of RE and controls (P<0.05). The expression of COX-2 were found in 20 out of 24 BE without dysplasia, and 12 out of 13 BE with dysplasia, but not in normal mucosa. Conclusion: The dysfunction of the LES is the main mechanism of BE, and COX-2 expression is an early event in the development of BE. |
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| Keywords: | Barrett's esophagus esophagus motor function esophagus lower sphincter pressure cyclooxygenase-2 |
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