血清HA、PLD、PCⅢ、LN、Ⅳ—C联合检测对慢性肝病的诊断价值探讨

目的:寻找肝纤维化等慢性肝病敏感可靠的血清学诊断指标。方法:对196例各型肝病联合检测血清透明质酸(HA)、脯氨酸肽酶(PLD)、Ⅲ型前胶原(PCⅢ)、层粘蛋白(LN)、Ⅳ型胶原(Ⅳ-C),并与10例肝组织学和30例健康献血员做对照研究。结果:五项指标分别在急性肝炎、慢性肝炎和肝硬变中依次升高,差异显著(P<0.05或P<0.01),其改变情况与轻、中、重型纤维化程度呈同步性,有良好的正相关。结论:五项指标联合检测可极大地增加慢性肝病临床诊断的准确性与可靠性,动态观察其变化可掌握病情演变。

The preliminary study on diagnostic value of co - detection of serum HA, PLD, PC ID , LN and IV - C in chronic hepatic diseases

Objective The study was designed to estabish sensitive and reliable serum marker on liver fibrosis etc. Chronic hepatic diseases for early clinical diagnosis, Methods We carried out co- detection of serum HA, PLD, PCIII, LN and IV - c in 196 cases with different hepatic diseases compared with liver - biopsy samples of 10 cases and 30 cases health volunteer blood. Results The five markers increase in the acute virus hepatitis, chronic hepatitis and cirrhosis progressively while the difference between groups were significant (P<0. 05 or P<0. 01). Conclusion The co - detection of five markers Can improve the accurency and reliability of clinical diagnosis. The dynamic changement of five markers may be used to predict the. trends of diseases.