大剂量尿激酶静脉溶栓治疗急性心肌梗塞的临床观察

用大剂量尿激酶(UK)静脉溶栓(进口UK50万U静推5～15分钟,100万U静点30分钟或国产UK100万U静推5～15分种,100万U静点30分钟滴完)治疗30例发病6小时内急性心肌梗塞(AMI),根据临床冠脉再通指标观察再通率为96.7％(29/30),明显高于UK50～150万U/60～90分种静脉溶栓再通率(50％～55％),亦与rt-PA、SK加速溶栓治疗的结果相一致。无脑出血及严重内脏出血。大剂量UK静脉溶栓治疗AMI是一种安全有效的方法,值得进一步研究和推广。

The clinical Observation of Hyper dose Urokinase Thrombolytic Therapy in Acute Myocardial Infarction

Thirty seven patients with acute myocardial infarction within 6hours after onset of symptoms were used with hyper dose urokinase (UK 150 ~ 200 million U) thrombolytic therapy intrvenously. The reperfusion rate of infarct - related arteries determined by clinical evidence of reperfusion was 96. 7% (29/30) , which was higher obviously than the reperfusion rate of UK 50 ~ 150 million U/60 - 90min thrombolytic intrvenously, without encephalorrhagia and internal organs serious bleeding complications. It is safe and effective that hyper dose urokinase thrombolytic therapy in acute myocardial infarction.