| 五味子醇甲的提取纯化工艺研究 |
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| 引用本文： | 范晨怡,章晓骅,魏惠华,施亚芳,孙明珍,陈彦,贾晓斌.五味子醇甲的提取纯化工艺研究[J].中国药房,2007,18(12):896-898. |
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| 作者姓名： | 范晨怡 章晓骅 魏惠华 施亚芳 孙明珍 陈彦 贾晓斌 |
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| 作者单位： | 1. 江苏省中医药研究院、江苏省现代中药制剂工程技术研究中心,南京市,210028
2. 天津市轩宏医药技术有限公司,天津市,300284 |
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| 摘 要： | 目的研究五味子中五味子醇甲的最佳提取、纯化工艺。方法以五味子醇甲及其提取物为指标,采用L9(34)正交试验优选合理的水提工艺,采用平行试验优选醇沉工艺参数。结果优选出的五味子醇甲提取、纯化工艺为用10倍量的水,提取3次,每次1.5h,滤液浓缩到1.4g生药·mL-1后醇沉至80%,醇液过滤,pH值调至7。结论本方法可为提取五味子的生产工艺提供参考。
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| 关 键 词： | 正交试验 五味子醇甲 提取工艺 纯化 |
| 文章编号： | 1001-0408(2007)12-0896-03 |
| 收稿时间： | 09 1 2006 12:00AM |
| 修稿时间： | 11 2 2006 12:00AM |
Study on the Extraction and Purification Process of Schisandrin |
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| FAN Chenyi,ZHANG Xiaohua,WEI Huihua,SHI Yafang,SUN Mingzhen,CHEN Yan,JIA Xiaobin.Study on the Extraction and Purification Process of Schisandrin[J].China Pharmacy,2007,18(12):896-898. |
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| Authors: | FAN Chenyi ZHANG Xiaohua WEI Huihua SHI Yafang SUN Mingzhen CHEN Yan JIA Xiaobin |
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| Abstract: | OBJECTIVE: To optimize the process for extraction and purification of Schisandrin in Fructus Schisandra Chinensis. METHODS: The orthogonal test L9( 34) was adopted to optimize the water extraction process using Schisandrin and its extracts as indicators. The parallel test was used to optimize the parameters of the alcohol precipitation technique. RESULTS: The optimized process for extraction and purification of Schisandrin was as follows: extracting three times using 10- fold water, 1. 5h each time, with filter liquids concentrated to 1. 4g of crude drug mL- 1 then precipitated to 80% ; filtering alcohol liquids, and adjusting pH value to 7. CONCLUSIONS: This method can be used as a reference for the extraction of Fructus Schisandra Chinensis. |
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| Keywords: | Orthogonal test Schisandrin Extraction process Purification |
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