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药物性肝损伤临床相关因素分析
引用本文:刘子声,殷国建,王少峰.药物性肝损伤临床相关因素分析[J].中国现代医药杂志,2011,13(12):21-24.
作者姓名:刘子声  殷国建  王少峰
作者单位:苏州大学附属第二医院消化科,215004
摘    要:目的探讨190例药物性肝损伤病例的病因、临床特点及预后相关因素,以指导临床诊断和治疗。方法对我院2006年1月~2010年12月190例药物性肝损伤住院病例进行回顾性研究,分析其用药、临床表现和预后转归情况。结果引起药物性肝损伤的药物品种繁多,其中抗肿瘤药占首位56例(29.4%),中药50例(26.3%);临床分型以肝细胞型为主152例(80.0%),胆汁淤积型24例(12.6%);临床表现无明显特异性,其中无任何临床表现者84例(44.2%),有明显黄疸者48例(25.3%);经治疗后治愈30例(15.8%),好转150例(78.9%),死亡0例,10例失访。结论近年来药物性肝损伤呈明显增加趋势,以抗肿瘤药及中药为主,一般预后较好。

关 键 词:药物性肝损伤  临床特点  回顾性分析

Retrospective analysis of drug-induced liver injury
Liu Zisheng,Yin Guojian,Wang Shaofeng.Retrospective analysis of drug-induced liver injury[J].Modern Medicine Journal of China,2011,13(12):21-24.
Authors:Liu Zisheng  Yin Guojian  Wang Shaofeng
Institution:Liu Zisheng,Yin Guojian,Wang Shaofeng.Department of Gastroenterology,the Second Affiliated Hospital of Soochow University,Suzhou 215004
Abstract:Objective To investigate the cause,clinical features,and prognosis of drug-induced liver injury.Methods Retrospectively analyzed the clinical data of 190 patients with drug-induced liver injury in our hospital from Jan 2006 to Dec 2010.Results A variety of drugs could cause liver injury.In the 190 cases,29.4% were induced by antineoplastic drugs,26.3% by Chinese herbal medicines;among those patients the rate of hepatocellular damage type was 80.0%,cholestatic damage type was 12.6%.84 cases(44.2%) never had ...
Keywords:Drug-induced liver injury Clinical feature Retrospective analysis  
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