| 西红花酸对动脉粥样硬化大鼠血脂及LOX-1表达的影响 |
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| 引用本文： | 蔡恒玲,刘应辉,刘娜娜. 西红花酸对动脉粥样硬化大鼠血脂及LOX-1表达的影响[J]. 中国现代医药杂志, 2011, 13(10): 3-5 |
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| 作者姓名： | 蔡恒玲 刘应辉 刘娜娜 |
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| 作者单位： | 南华大学病原生物学研究所,湖南衡阳,421001 |
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| 基金项目： | 湖南省科技厅科研条件创新专项 |
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| 摘 要： | 目的研究西红花酸对动脉粥样硬化大鼠血脂及LOX-1表达的影响。方法健康SD雄性大鼠,随机分为4组:空白对照组、模型组、西红花酸高剂量组、西红花酸低剂量组。高脂饲料建立大鼠实验性动脉粥样硬化模型,测定大鼠血清总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白。同时取主动脉做病理切片检查。RT-PCR、Westernblotting技术检测主动脉LOX-1的基因与蛋白表达水平,观察西红花酸对其血管平滑肌细胞LOX-1表达的影响。结果高、低剂量的西红花酸能显著降低动脉粥样硬化大鼠血清TC、TG和LDL-C含量;明显降低主动脉LOX-1的表达。结论西红花酸可明显下调动脉粥样硬化大鼠LOX-1的表达。
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| 关 键 词： | 西红花酸 动脉粥样硬化 大鼠 血脂 LOX-1 |
Effects of crocetin on serum lipid and expression of LOX-1 in atherosclerosis rats |
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| Cai Hengling,Liu Yinghui,Liu Nana. Effects of crocetin on serum lipid and expression of LOX-1 in atherosclerosis rats[J]. Modern Medicine Journal of China, 2011, 13(10): 3-5 |
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| Authors: | Cai Hengling Liu Yinghui Liu Nana |
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| Affiliation: | Cai Hengling,Liu Yinghui,Liu Nana.Institute of Pathogenic Biology-University of South China,Hengyang 421001 |
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| Abstract: | Objective To study the effects of crocetin on expression of LOX-1 in atherosclerosis rats.Methods Healthy male SD rats were randomly divided into 4 groups:control group,model group,high-crocetin group,low-crocetin group.Atherosclerosis rats were established by feeding the animals with a high lipid diet.Serum level of TC(total cholesterol),TG(triglycerides),LDL-C(low density lipoprotein cholesterol),and HDL-C(high density lipoprotein cholesterol) were determined.The aorta was taken for pathological sections.... |
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| Keywords: | Crocetin Atherosclerosis Rat Serum lipid LOX-1 |
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