| 氟桂利嗪对脑缺血再灌损伤HSP70基因表达减少神经细胞损伤的影响 |
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| 引用本文： | 谷文萍,周琳,刘威,杨期东,曹贵方,谢光洁,杨杰,周艳宏.氟桂利嗪对脑缺血再灌损伤HSP70基因表达减少神经细胞损伤的影响[J].中国组织工程研究与临床康复,2002,6(23):3611-3612. |
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| 作者姓名： | 谷文萍 周琳 刘威 杨期东 曹贵方 谢光洁 杨杰 周艳宏 |
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| 作者单位： | The Institute of Neurology，The Institute of Neurology，The Institute of Neurology，The Institute of Neurology，The Institute of Neurology，The Institute of Neurology，The Institute of Neurology，The Institute of Neurology Xiangya Hospital，Central South University，Changsha410008，China，Xiangya Hospital，Central South University，Changsha410008，China，Xiangya Hospital，Central South University，Changsha410008，China，Xiangya Hospital，Central South University，Changsha410008，China，Xiangya Hospital，Central South University，Changsha410008，China，Xiangya Hospital，Central South University，Changsha410008，China，Xiangya Hospital，Central South University，Changsha410008，China，Xiangya Hospital，Central South University，Changsha410008，China |
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| 摘 要： | Asakindofselectivecalciumantagonist,Flunarizine(FNZ)iswidelyusedtotreattheischemiccerebrovasculardiseaseinclinic.WewonderwhetherFNZcanaffecttheexpressionofHSP70andapoptoticgeneornotwhileitisabletoprotectcellsfromtheischemiccerebralinjuries.Ourresearchisdescribedindetailasbelow.1Materialsandmethods1.1Thegroupingandpreparationofanimals60healthymaleGerbils(providedbyShanghaimedicalexperimentanimaladminis-trationcommittee),weightwithintherangeof(100±10)g,wererandomlydividedintoseveralgroups.…
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Effect of flunarizine on HSP70 gene expression for following transient ischemia |
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| GU Wen ping,ZHOU Lin,LIU Wei,YANG Qi dong.,CAO Gui fang,XIE Guang jie,YANG Jie,ZHOU Yan hong.Effect of flunarizine on HSP70 gene expression for following transient ischemia[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2002,6(23):3611-3612. |
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| Authors: | GU Wen ping ZHOU Lin LIU Wei YANG Qi dong CAO Gui fang XIE Guang jie YANG Jie ZHOU Yan hong |
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| Abstract: | Objective To investigate the effects of flunarizine on HSP70 gene expression for following transient ischemia.Methods Northern blot and immunohistochmistry (IHC) were used to determine the expression of the HSP70 during different periods after post ischemic reperfusion with or without Flunarizine treatment in the gerbil. Results The HSP70mRNA expression was increased in the forebrain,but the HSP70 protein only expressed at the 1st day of reperfusion(P<0.05);Flunarizine treatment could increase the expression of HSP70 protein, but couldn't significantly increase the expression of HSP70 mRNA (P >0.05). Conclusion Flunarizine could protect neurons from ischemic damage through increasing the HSP70 expression. |
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| Keywords: | cerebral ischemia HSP70 funarizine |
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