| 上皮间质转化的信号转导调控及药物开发 |
| |
| 引用本文： | 徐思云,李静,耿美玉.上皮间质转化的信号转导调控及药物开发[J].中国药理学通报,2008,24(9). |
| |
| 作者姓名： | 徐思云 李静 耿美玉 |
| |
| 作者单位： | 中国海洋大学医药学院,山东,青岛266003 |
| |
| 基金项目： | 国家高技术研究发展计划(863计划) |
| |
| 摘 要： | 上皮间质转化(epithelial-mesenchym al-transition,EMT)是胚胎形成过程中的关键步骤,研究表明其在原发性肿瘤转移过程中同样发挥了重要作用。参与EMT的信号通路包括Wnt/β-catenin、Notch、Hedgehog、TGFβ和生长因子受体等,针对相应信号通路的药物成为有效的恶性肿瘤治疗手段。
|
| 关 键 词： | 上皮细胞 间充质细胞 上皮间质转化 信号转导 肿瘤转移 |
The signal transduction and drug development of epithelial-mesenchymal transition |
| |
| XU Si-yun,LI Jing,GENG Mei-yu.The signal transduction and drug development of epithelial-mesenchymal transition[J].Chinese Pharmacological Bulletin,2008,24(9). |
| |
| Authors: | XU Si-yun LI Jing GENG Mei-yu |
| |
| Abstract: | Epithelial-mesenchymal-transition(EMT) plays a key role in the formation of embryo.At present,it is believed that EMT also contribute to the metastasis of primary tumors.A lot of signaling pathways participate in EMT,such as Wnt/β-catenin,Notch,Hedgehog,TGFβ and growth factor receptors.The drugs that affect these pathways may play an important part in oncotherapy. |
| |
| Keywords: | epithelial cell mesenchymal cell epithelial-mesenchymal-transition signaling transduction tumor metastasis |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
