还元注射液对急性脑出血患者血浆内皮素与降钙基因相关肽的影响

目的:阐明还元注射液治疗急性脑出血的作用机理。方法:将45例急性脑出血患者随机分为还元组和甘露醇组,分别给予还元注射液和20%甘露醇治疗,并辅以维生素C、10%KCl等静脉滴注,共治疗2周。于治疗前、后分别测定血浆内皮素(ET)、降钙基因相关肽(CGRP)。结果:治疗2周后,还元组较治疗前血浆ET水平明显降低,CGRP含量明显增高(P<001);甘露醇组治疗前后无统计学差异(P>005);两组治疗后比较,血浆ET与CGRP均有显著性差异(P<005)。结论:还元注射液治疗急性脑出血的作用机理与降低患者血浆ET水平,提高CGRP含量有关。

Effect of Huanyuan Injection on Plasma Endothelin and Plasma Calcitonin Gene Related Peptide in Acute Intracerebral Hemorrhage

To study the mechanism of Huanyuan injection in treating acute intracerebral hemorrhage. Methods: Forty five patients were divided into Huanyuan group and mannitol group who were treated with Huanyuan injection and mannitol intravenously for two weeks respectively. Meanwhile, the two groups were also treated with vitamin C, potassium chloride, etc, intravenously. Plasma endothelin (ET) and calcitonin gene related peptide (CGRP) levels were determined before and after treatment. Results: After treatment for two weeks, changes of plasma ET and CGRP in mannitol group was insignificant (P>0 05). Compared with the two treated group, There was obvious significance in plasma ET levels and CGRP content (P<0 05). Conclusion: Therapeutic mechanism of Huanyuan injection in treating acute intracerebral hemorrhag were correlated to reduce plasma ET and raise the CGRP levels.