Labelling of Re-ABP with 188Re for bone pain palliation. |
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Authors: | C Arteaga de Murphy G Ferro-Flores M Pedraza-López L Meléndez-Alafort B Y Croft F M Ramírez J Padilla |
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Affiliation: | Departamento de Medicina Nuclear, Instituto Nacional de Nutrición Salvador Zubirán, México DF, Mexico. cmurphy@data.net.mx |
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Abstract: | Etidronate and medronate have been labelled with technetium-99m (99mTc-HEDP, 99mTc-MDP) for bone scanning and, with rhenium-188 (188Re-HEDP) to palliate the pain resulting from bone metastases. The objective of this study was to label alendronate, ABP, a new bisphosphonate, with SnF2-reduced-188Re. The reagents for the 5 mg ABP kit were SnF2, KReO4 and gentisic acid at acid pH. The chemical, spectroscopic and microscopic characteristics, quality control, rat bone uptake of [188Re]Re-ABP and similarities with 99mTc-ABP are presented. We conclude that this is a promising new radiopharmaceutical for bone metastases pain palliation. |
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