女性首发精神分裂症患者糖调节异常临床研究

目的探讨女性首发分裂症患者中糖调节异常（IGR）的发生情况及糖化血红爱白（HbA1C）用于筛选IGR的可行性。方法首发、未经治疗的女性精神分裂症（180例），及正常对照组（180例），测定空腹血糖（FPG）、糖耐量试验2h血糖值（2HPG），病例组尚测定HbA1C，按WHO标准诊断。结果病例组FPG、2HPG均高于对照组，差异有显著性（P〈0．01）；患者组诊断IGR38例（21．1％），高于对照组10例（5，6％），差异有显著性（P〈0．01）；单因素分析、多因素分析均显示，精神分裂症与IGR间存在具有统计学意义的关联（分别OR=4．55、4．64，均P〈0．01）。HbA1C对IGR诊断阳性率与金标准比较，差异无显著性（P〉0．05）。结论女性首发精神分裂症IGR高发，HbA1C检查可用于IGR筛选。

A case-control study on impaired glucose regulation in first-episode female patients with schizophrenia

ObjectiveTo investigate the prevalence of impaired glucose regulation(IGR) in first-episode female patients with schizophrenia, and primarily assess the possibility of glycated hemoglobin A_ 1c (HbA_ 1C) used for screening IGR.MethodsFirst-episode drug-naive female patients with schizophrenia (180 cases) and healthy normal controls (180 cases) were involved in the study. The fasting plasma glucose (FPG) and 2-hour plasma glucose in the oral glucose tolerance test (2HPG) were determined in two groups ,and HbA_ 1C was determined in case group.The diagnosis of IGR was made according to the WHO criteria. ResultsFPG and 2HPG were significantly higher in cases than in controls (P<0.01).The prevalence of IGR in cases was significantly higher than in controls(21.1% vs 5.6%,P<0.001). With univariable and multivariable analysis, the schizophrenia showed a significant association with IGR(OR=4.55,4.64,both P<0.01).The positive rate of IGR according to HbA_ 1C was similar as according to gold standard , and no statistically significant difference was found between them(P>0.05).ConclusionThe prevalence of IGR in first-episode female patients with schizophrenia is higher than in controls. HbA_ 1C measuring could be used for screening IGR.