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BCR-ABL rearrangement in a child with acute myelogeneous leukaemia without a Philadelphia chromosome |
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| Authors: | A Borkhardt R Repp J Harbott M Lakomek J W G Janssen † S Schlieben C R Bartram † F Lampert |
| Institution: | Department of Paediatric Oncology, Children's University Hospital, Giessen;Department of Paediatric Oncology, Children's University Hospital, Göttingen;Section of Molecular Biology, Department of Paediatrics II, University of Ulm, Ulm, Germany |
| Abstract: | Summary. We describe a BCR/ABL rearrangement positive but Philadelphia chromosome negative status in a 9-year-old boy suffering from an acute myelogeneous leukaemia (AML). This case was detected in a prospective PCR screening procedure including 21 children with newly diagnosed AML and 150 children with acute lymphoblastic leukaemia (ALL). We found a 5·4% incidence of BCR/ABL rearrangement positive cases in pre-B and c-ALL in childhood. |
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