胰腺癌预后的多因素分析

目的：探讨影响胰腺癌的预后因素．方法：对资料完整的胰腺癌病例113例进行回顾性统计，应用COX比例风险模型对9项指标进行了多因素分析，并用Kaplan-Meier法计算其生存率．结果：本组生存期0．1～82 mo，中位生存期3 mo，6，12，18，36 mo的生存率分别为35．6％，20．3％，15．9％，6．2％．多变量分析显示，影响胰腺癌预后最明显的因素是黄疸、转移、治疗方式以及是否行综合治疗．结论：胰腺癌预后由多种因素决定，伴有黄疸、转移的胰腺癌患预后差，行根治性切除术、综合治疗可改善预后．

Prognostic factors in patients with pancreatic carcinoma

AIM: To evaluate the major prognostic factors in patients with pancreatic carcinoma. METHODS: 113 cases of pancreatic carcinoma were retrospective analyzed and 9 factors for prognosis were studied by multivariate analysis with Cox proportional hazards survival model. Survival rate was calculated by Kaplan Meier estimation. RESULTS: In this group, the survival time was 0.1 to 82 months and the median survival time was 3 months. Overall survival rates at 6, 12, 18, 36 months were 35.6%, 20.3%, 15.9% and 6.2%, respectively. Multivariate analyses revealed that the most significant factors that affecting prognosis of pancreatic carcinoma were jaundice, metastasis, therapeutic method and with or without integrated therapy. CONCLUSION: The prognosis of pancreatic carcinoma is affected by various factors. Jaundice and metastasis were predictors of poor survival. Surgical operation and integrated therapy can improve the prognosis.