肺癌放疗或化疗后肿瘤内浸润细胞的免疫组化研究

本文对３７例放疗或化疗后肺癌组织内淋巴细胞和巨噬细胞进行单克隆抗体Ｐａｎ－Ｔ，Ｐａｎ－Ｂ和Ｋｐ１免疫组化标记，并与５８例未接受放疗或化疗肺癌作对比观察分析。结果表明两组肺癌局部反应主要为Ｔ淋巴细胞和巨噬细胞，大多数位于癌间质，少数位于癌巢内。部分肿瘤内有Ｂ淋巴细胞。治疗组肿瘤内Ｔ细胞和巨噬细胞明显多于未治疗组（Ｐ＜０．０５或Ｐ＜０．０１）。这可能是机体对治疗后癌细胞所释放的某种抗原物质的一种免疫反应。

Immunohistochemical study of infiltrating cells in lung cancer after radiotherapy or chemotherapy

Thirty-seven specimens of lung cancer treated with radiotherapy or chemotherapy were studied with immunohistochemical methods of Pan-T, Pan-B and Kp1 and other 58 lung cancer specimens without radio-or chemotherapy were studied likewise to serve as the control.It was found that the infiltrating cells in both the groups were mainly T-lymphocytes and macrophages,of which most distributed in the interstitial tissue and some in the cancerous nests. B-lymphocytes were found in a part of the specimens.The number of infiltrating T-cells and macrophages was significantly larger in the treated group than in the control(P<0.05 to 0.01),which might be due to an immune reaction against certain antigenic substance released by the cancerous cells after treatment.