| 高效液相色谱法测定人血浆中卡马西平血药浓度 |
| |
| 引用本文： | 王岩,高勇.高效液相色谱法测定人血浆中卡马西平血药浓度[J].实用药物与临床,2005,8(3):16-17. |
| |
| 作者姓名： | 王岩 高勇 |
| |
| 作者单位： | 1. 中国医科大学附属第一医院药剂科,沈阳,110001
2. 中国医科大学附属第二医院药剂科,沈阳,110004 |
| |
| 摘 要： | 目的建立一种快速、方便、准确的方法测定卡马西平血药浓度。方法用RP-HPLC法测定卡马西平血药浓度。结果线性范围0.4-25μg/ml,最低检测浓度0.15μg/ml,最低定量浓度0.4μg/ml,回归方程Y=12.5X+0.1425(r=0.9960)。回收率为97.5%,日内和日间精密度分别为RSD=1.5%和RSD=2.3%。结论本法准确、快速,适合临床上血药浓度检测。
|
| 关 键 词： | 卡马西平 高效液相色谱法 浓度 |
| 文章编号： | 1673-0070(2005)03-0016-02 |
| 修稿时间： | 2004年9月12日 |
Determination of Concentration of Carbamazepine in Human Plasma by HPLC |
| |
| WANG Yan,GAO Yong.Determination of Concentration of Carbamazepine in Human Plasma by HPLC[J].Practical Pharmacy and Clinical Remedies,2005,8(3):16-17. |
| |
| Authors: | WANG Yan GAO Yong |
| |
| Abstract: | Objective To establish a rapid, convenient and accurate method to determine the concentration of car-bamazepine in human plasma. Methods The concentration of carbamazepine was determined by RP-HPLC. Results The linearity range was 0.4-25μg/ml with a regressive equation of Y= 12.5X + 0.142 5, r = 0.996 0. The recovery rate was 97.5 % . RSD was 1.5% (intra-day) and 2.3% (inter-day) . Conclusion The method is accurate and rapid and suitable for determination of carbamazepine in human plasma. |
| |
| Keywords: | HPLC carbamazepine concentration |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
