| 高效液相色谱法测定曲克芦丁注射剂的含量 |
| |
| 引用本文： | 刘同华,卢来春.高效液相色谱法测定曲克芦丁注射剂的含量[J].中国药房,2004,15(6):365-366. |
| |
| 作者姓名： | 刘同华 卢来春 |
| |
| 作者单位： | 第三军医大学新桥医院药学部,重庆市,400037 |
| |
| 摘 要： | 目的 :建立以高效液相色谱法测定曲克芦丁注射剂含量的方法。方法 :色谱柱为HypersilBDSC18(150mm×5mm ) ,流动相为乙腈 -四氢呋喃 -0 05mol/L磷酸二氢钠溶液 (15∶8∶77 ,pH=4 0) ,柱温为30℃ ,流速为0 8ml/min ,检测波长为254nm。结果 :曲克芦丁标准溶液浓度在20～200μg/ml范围内线性关系良好 (r=0 9998) ,平均回收率为100 7 %;高、中、低3种浓度曲克芦丁样品溶液日内精密度为1 61 %,日间精密度为2 46 %。结论 :该方法简便 ,结果准确 ,适用于曲克芦丁注射剂的质量控制。
|
| 关 键 词： | 曲克芦丁 注射剂 高效液相色谱法 含量 |
| 文章编号： | 1001-0408(2004)06-0365-02 |
| 修稿时间： | 2004年4月9日 |
Quantitative Determination of Troxerutin Injection by HPLC |
| |
| LIU Tonghua,LU Laichun.Quantitative Determination of Troxerutin Injection by HPLC[J].China Pharmacy,2004,15(6):365-366. |
| |
| Authors: | LIU Tonghua LU Laichun |
| |
| Abstract: | OBJECTIVE :To determine the content of Troxerutin in Troxerutin injection by HPLC METHODS :The separation was performed on a Hypersil BDS C18 column The mobile phase was composed of acetontrile-tetrahydrofuran-0.05 mol/Lsodium dihydrogen phosphate(15∶8∶77V/V ) ,adjusted to pH4 0 with phosphoric acid The flow rate was 0 8ml/ min The ultraviolet wavelength was 254nm RESULTS :The calibration curve showed good li nearityinrange of (20～200) μg/ ml(r=0 9998) ;The mean recovery was 100 7 % The within -day RSD was 1 61 %,and inter-day RSD was 2 46 % CONC_ LUSION :The method was simple ,convenient and accurate and can be used for the quality control of Troxerutin injection |
| |
| Keywords: | Troxerutin injection HPLC content |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
