Synthesis and antimicrobial activities of some new triazolothiadiazoles bearing 4-methylthiobenzyl moiety |
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Authors: | Prasad D Jagadeesh Ashok Mithun Karegoudar Prakash Poojary Boja Holla B Shivarama Kumari Nalilu Sucheta |
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Affiliation: | Department of Chemistry, Mangalore University, Mangalagangothri 574199, Karnataka, India. jprasad_2003@yahoo.co.in |
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Abstract: | A series of substituted triazolothiadiazoles have been synthesized by condensing 4-amino-3-[4-methylthiobenzyl]-4H-1,2,4-triazole-5-thiol (5) with substituted aryl furoic acids/aromatic acids in the presence of POCl3. The triazole (5) was obtained by the fusion of 4-methylthiophenyl acetic acid with thiocarbohydrazide. The structures of newly synthesized compounds are characterized by elemental analysis, IR, 1H NMR and mass spectroscopic studies and were screened for their antimicrobial activities. The preliminary results revealed that some of the compounds exhibited promising antimicrobial activities. |
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