| 特发性肺纤维化患者IL-6水平与T细胞功能的检测 |
| |
| 作者单位： | Dept. of Respiratory Diseases，The second Clinical College |
| |
| 摘 要： | 采用生物活性检测法，观察特发性肺纤维化（IPF）患者外周血单个核细胞（PBMC）自泌白细胞介素6（IL－6）水平及白细胞分化抗原3（CD3）单克隆抗体（McAb）诱导下的T细胞功能。结果表明：IPF患者IL－6自泌水平明显高于正常对照组（P＜0．001）；在体外CD3McAb诱导下，IPF患者T细胞对抗原免疫应答能力与T细胞在体内的活化过程大致相符，且对IL－6分泌呈异常高表达。提示IL－6分泌水平与IPF病情相关。
|
| 关 键 词： | 特发性肺纤维化 白细胞介素6 T细胞 白细胞分化抗原3单克隆抗体 |
Detection of IL-6 level and T cell's functions in patients with idopathic pulmonary fibrosis |
| |
| Authors: | An Jihong Cheng Guanghui Zhang Jie |
| |
| Abstract: | We observed the self-secretion IL-6 levels of peripheral blood monocytes and T cell's functions induced by CO3McAb in the patients with IPF by means of the bioassay. The results are asfollows: 1. The self-secretion IL-6 levels remarkably increased in the IPF cases than those of controls. (P<0. 001) 2. The immune responses induced by antigen in the patients with IPF matched theactivated process of T cell in vitro, The results suggested that the secretion level of IL-6 might correlate with lPF condition. |
| |
| Keywords: | IPF IL- 6 T-Cell CO_3McAb |
| 本文献已被 CNKI 等数据库收录！ |
