| HBeAg阳性/阴性慢性乙型肝炎患者血清HBV DNA与肝组织炎症的相关性 |
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| 引用本文： | 杨岩,张小亚,盛慧萍,赖娅芳,王国宁. HBeAg阳性/阴性慢性乙型肝炎患者血清HBV DNA与肝组织炎症的相关性[J]. 宁夏医科大学学报, 2011, 0(6): 525-527 |
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| 作者姓名： | 杨岩 张小亚 盛慧萍 赖娅芳 王国宁 |
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| 作者单位： | 宁夏医科大学总医院感染性疾病科;宁夏医科大学研究生学院; |
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| 基金项目： | 宁夏回族自治区自然科学基金(NZ10148) |
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| 摘 要： | 目的探讨慢性乙型肝炎患者乙型肝炎e抗原（HBeAg）阳性与阴性血清乙肝病毒脱氧核糖核酸（HBVDNA）水平与肝组织炎症分级的相关性。方法将121例慢性乙型肝炎患者分为HBeAg阳性组（62例）及阴性组（59例）,乙型肝炎病毒（HBV）血清标志物用化学发光法检测;丙氨酸氨基转移酶（ALT）用全自动生化分析仪检测;血清HBV DNA定量检测采用荧光定量聚合酶链反应法;肝组织行常规病理染色判断炎症活动度。结果 HBeAg阴性组和阳性组平均年龄及病程分别为（36.95±8.5）岁和（33.23±10.42）岁（,118.79±72.29）个月和（82.45±52.24）个月（两组比较均P〈0.05）;HBeAg阳性组和阴性组血清HBV DNA定量及ALT水平分别为（6.43±1.18）IU.mL-1 vs（4.16±2.48）IU.mL-1（、222.54±272.68）IU.L-1 vs（134.88±120.85）IU.L-1（两组比较均P〈0.05）;HBeAg阳性组血清HBV DNA定量与肝组织炎症分级相关性检验rs=-0.095,P〉0.05;HBeAg阴性组血清HBV DNA定量与肝组织炎症分级相关性检验rs=0.261,P〈0.05。结论 HBeAg阳性与阴性的慢性乙型肝炎的的临床表现及病理学特点有所不同,慢性乙型肝炎的病变程度应综合一般临床资料、血清HBV DNA水平及肝穿刺病理来共同评判。
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| 关 键 词： | 慢性乙型肝炎 乙型肝炎病毒e抗原 DNA病毒 |
Relationship between Serum HBV DNA Level and Hepatic Inflammation Degree in Patients with HBeAg-positive and HBeAg-negative Chronic Hepatitis B |
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| YANG Yan,ZHANG Xiao-ya,SHENG Hui-ping,LAI Ya-fang,WANG Guo-ning. Relationship between Serum HBV DNA Level and Hepatic Inflammation Degree in Patients with HBeAg-positive and HBeAg-negative Chronic Hepatitis B[J]. Journal of Ningxia Medical College, 2011, 0(6): 525-527 |
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| Authors: | YANG Yan ZHANG Xiao-ya SHENG Hui-ping LAI Ya-fang WANG Guo-ning |
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| Affiliation: | YANG Yan1,ZHANG Xiao-ya2,SHENG Hui-ping1,LAI Ya-fang2,WANG Guo-ning2 (1.Dept.of Infection,the General Hosptital of Ningxia Med.Univ.,Yinchuan 750004,2.Ningxia Med.Univ.,Yinchuan 750004) |
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| Abstract: | Objective To investigate the relationship between serum HBV DNA levels and liver inflammation grade(G) in chronic hepatitis B patients with HBeAg-positive and HBeAg-negative.Methods 121 patients with chronic hepatitis B were divided into HBeAg-positive group(62 cases) and HBeAg-negative(59 cases).The serum hepatitis B virus(HBV) markers were detected by chemiluminescence.The alanine aminotransferase(ALT) were detected by automatic biochemical analyzer.The serum HBV DNA quantitation were detected by fluoresc... |
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| Keywords: | chronic B hepatitis hepatitis B e-antigen DNA virus |
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