剑桥认知检查(CAMCOG)对血管性痴呆与阿尔茨海默病的神经心理学鉴别

目的 验证剑桥认知检查(CAMCOG)对血管性痴呆(VaD)与阿尔茨海默病(AD)是否具有神经心理学鉴别功能。方法 所有入选病例皆符合很可能／可能AD或VaD的诊断标准。325例中，246例AD患 者和79例VaD患者接受了CAMCOG检查。性别和其他因素比率分析用卡方检验，所有其他参数的比较分析用t检验，组间分类用逐步辨别分析方法。结果 AD组CAMCOG平均总积分低于VaD组7分以上，其中定向力、语言、记忆和视觉积分与VaD组相比具有显著性差异。这些分项积分和CAMCOG总积分对组间辨别功能具有显著贡献，对AD或VaD诊断预测的总成功率达到70％．结论 在CAMCOG区城内，AD患者和VaD患者的神经心理学表现具有显著性差异，但这种鉴别方法目前还不适宜于临床使用。

Neuropsychological differentiation between vascular dementia and Alzheimer's disease

Objective To document some of the ways in which neuropsychological tests can distinguish AD from VaD by means of the CAMCOG Methods This database-based study was designed as a comparison between AD and VaD on neuropsychological tests All subjects selected for inclusion were those with a diagnosis of probable/possible AD or VaD Of 325 subjects, there were 246 patients with AD and 79 with VaD, who were interviewed using the CAMCOG Analysis of gender and ratio of other factors was done by the Chi-square test Comparison of all other parameters was analysed by t-test A stepwise discriminant analysis of the classification was also employed Results The mean total CAMCOG score in AD group was over 7 points lower than VaD group There were also significant differences in Orientation, Language, Memory and Visual perception of the CAMCOG subscale scores in AD compared with VaD These subscales and the CAMCOG total score were significant contributions to discriminant function The overall success rate for predictions of membership of AD or VaD was up to 70%.Conclusions Significant differences existed in neuropsychological performance of AD patients and VaD patients on CAMCOG domain The differentiation methods are currently unsuitable for clinical use