PI3K与PTEN蛋白在口腔鳞癌中的表达及相关性研究

目的：探讨口腔鳞癌中PTEN、PI3K的表达情况，并对其表达水平与临床特征之间的关系进行相关性分析，探讨其与口腔鳞癌发生、发展和转移的关系。方法采用免疫组化SP法对52例口腔鳞癌石蜡标本及20例癌旁正常组织中PTEN、PI3K蛋白的表达情况进行研究，分析其与临床病理特征的关系。结果 PTEN在口腔鳞癌中表达明显低于癌旁正常组织。PI3K表达明显高于癌旁正常组织。PTEN与PI3K表达与细胞分化、临床分期、淋巴结转移相关。PTEN与PI3K阳性表达之间呈负相关。结论 PI3K在口腔鳞癌中的表达上调， PTEN在口腔鳞癌中的表达下调。PTEN与PI3K蛋白表达呈负相关。

Expression and signiifcance of PI3K and PTEN proteins in oral squamous cell carcinoma

Objective To examine the expression and clinical and pathological significance of PTEN and PI3K in oral squamous cell carcinoma(OSCC).Methods Expression levels of PTEN, PI3K protein were determined using immunohistochemistry SP in 52 cases of OSCC and 20 specimens of normal oral mucosa tissues. The correlation between PTEN and PI3K protein and between the two markers and clinical and pathological parameters was analyzed.Results The PTEN level in OSCC was significantly lower than that in control, and level of PI3K was significantly higher than that in control. The expression of PTEN and PI3K was related to differentiation, stage, lymph node metastasis. The expression of PTEN protein was negatively correlated to that of PI3K.Conclusion The PI3K expression was up-regulated and PTEN expression down-regulated. Both PI3K and PTEN expression was related to stage and lymph node metastasis. The expression of PTEN protein was negatively correlated to that of PI3K.