介入治疗对急性冠脉综合征患者心肌生物能量消耗与脑钠肽的影响

【目的】通过观察急性冠脉综合征（ACS）经皮冠脉介入治疗（PCI）前后心肌生物能量消耗（MEE）及血浆氨基末端脑钠肽前体（NT-proBNP）的变化，探讨PCI治疗对ACS患者心功能改善的意义。【方法】本院ACS患者110例，随机分成急诊或择期PCI治疗组（A组，54例），药物治疗组（B组，56例），入院即刻、PCI治疗或药物治疗10d采血检测NTproBNP。同时对患者行超声心动图检测，根据公式计算出MEE，比较患者治疗前后MEE的变化及NT-proBNP的水平。【结果】两组患者治疗前MEE及NT-proBNP水平相比较差异无显著性（P〉0．05），两组患者治疗后MEE及NTproBNP水平较治疗前明显下降，且差异有显著性（P〈0．01）；治疗后A组NT-proBNP及MEE的改善作用明显优于B组，且两组相比较差异有显著性（P〈0．01）。【结论】PCI治疗能有效的改善ACS患者心肌细胞缺血状况，使NT-proBNP显著降低，继而也减低心肌能量消耗，改善了左心室收缩功能状况，减少心衰的发生。

Influence of Percutaneous Coronary Intervention on Myocardial Energy Expenditure and Brain Natriuretic Peptide in Patients With Acute Coronary Syndrome

Objective] To observe myocardial energy expenditure（MEE） and the change of brain natriuretic peptide（NT-proBNP） in acute coronary syndrome（ACS） before and after percutaneous coronary intervention（PCI）, and explore the significance o{ PCI for improving the cardiac function of ACS patients. Methods] Totally 110 ACS patients in our hospital were randomly divided into emergency or elective PCI group （group A, n =54） and drug therapy group（group B, n=56）. Blood was drawn to measure NT proBNP at immediate admission and 10d after PCI or drug therapy. Simultaneously, echocardiography was performed in patients. MEE was calculated by formula. The change of MEE and NT proBNP of patients before and after treatment was compared. Results] There was no significant difference in MEE and NT-proBNP before treatment between two groups（ P 〉0.05）. Compared with before treatment, MEE and NT-proBNP in two groups after treatment obviously decreased, and there was significant difference（ P 〈0. 01）. The improvement of NT-proBNP and MEE in group A after treatment were obviously better than group B, and there was significant difference between two groups（ P d0.01）. Conclusion] PCI treatment can effectively improve and alleviate ischemic myocardial cells in ACS patients, and markedly decrease NT-proBNP, and then reduce MEE, improve left ventricular systolic function and reduce the incidence of heart failure.