低能量激光照射对牙周炎的治疗效应研究

目的观察牙周基础治疗结合低能量激光照射疗法（LLLT）对牙周炎的治疗效果。方法选择18例慢性牙周炎患者共80颗患牙，左右对称，随机确定一侧为实验组（基础治疗加激光），对侧牙为对照组（基础治疗）。口腔卫生宣教和龈上洁治后1周为基线，治疗1周、4周和12周时，检测龈沟出血指数（SBI）、牙周探诊深度（PD）、临床附着丧失（CAL）；收集2组的龈沟液，用ELISA法检测其中的碱性成纤维细胞生长因子（b．FGF）、IL．113和IL．8的水平，并比较其变化。结果SBI、PD的变化：1周时仅SBI实验组与基线相比，差异具有统计学意义（P〈O．05）；4周时实验组和对照组分别与基线相比，其差异均具有统计学意义（P〈O．05）；12周时对照组与基线相比，差异有统计学意义（P〈0．05），实验组差异更为显著（P〈0．01）。2组SBI均在PD~〉6mm时下降最明显。CAL的改善：4周时实验组与基线相比，差异具有统计学意义（P（．0．05）；12周时与基线相比，对照组差异具有统计学意义（P〈0．05），实验组效果更为显著（P〈0．01）。b-FGF的水平：治疗后与基线相比，实验组持续上升，对照组先下降后回升到基线水平，12周时2组相比，差异具有统计学意义（P〈O．05）。IL．1B和IL-8的变化：12周时，实验组的变化优于对照组，2组间相比，其差异无统计学意义（侈0．05）。结论LLLT通过降低患者SBI、减少PD、改善CAL和增加龈沟液b-FGF的水平等途径可加速牙周组织的愈合。

Study on the effect of low level laser in the treatment of periodontal disease

Objective The purpose of this study was to explore the efficacy of low level laser treatment （LLLT） combined with initial periodontal therapy in treating chronic periodontits. Methods Eighteen patients with chronic periodontitis were randomly treated in a spit-mouth design with combination of laser （808 nm, 80 mW） treatment with scaling and root planing （experimental） or with scaling and root planing alone （contot） after OHI and supragingival cleaning. Clinical parameters of sulcus bleeding index （SBI）, periodontal probing depth （PD） and clinical attachment loss （CAL） of both sides were recorded and gingival crevicular fluid samples were collected at baseline and 1, 4, 12 weeks after the treatment. GCF samples were analyzed for b-FGF, IL-113, IL-8 level using ELISA assay. Results For the change of SBI and PD, only SBI in the experimental group experienced significant reduction （P〈0.05） at 1 week compared with baseline （P〈O.05）, and the reduction in both groups were statistically significant （P〈O.05） at 4 weeks. The same situation occurred while both experimental groups made more significant difference （P〈0.01） at 12 weeks. The reduction of SBI was obvious in both groups when the PD was more than 6 mm. For CAL, the experimental group showed signs of improvement （P〈O.05） at 4 weeks; both groups indicated improvement （P〈0.05）, while the experimental was more significant （P〈0.01） at 12 weeks. For the levels of b-FGF, it showed steady rise after treatment in experimental group,while it went up to the baseline after falling in control group. At 12 weeks, there were statistical significance of differences between two groups （P〈O.05）. The changes of IL-113 and IL-8, in the experimental group showed better results than that in control group, while the difference between two groups was not significant （/9〉0.05）. Conclusion LLLI can accelerate the healing of periodontal tissue by reducing the SBI, decreasing the PD, improving the CAL and increasing levels of b-FGF in the GCF of the patients.