2型糖尿病患者认知功能障碍与同型半胱氨酸的关系及危险因素分析

【目的】探讨2型糖尿病（T2DM）患者认知功能障碍与同型半胱氨酸（Hcy）的关系及认知功能障碍危险因素的分析。【方法】比较185例T2DM患者和80例健康对照组的血糖、血脂、尿素氮（BUN）、血肌酐（Cr）、同型半胱氨酸（Hcy）等多项指标，并对T2DM患者进行简易精神状态量表（MMSE）评分检查，分析上述指标与认知功能障碍的关系。【结果】①T2DM患者Hcy水平明显高于对照组，且合并高血压、脑梗死、冠心病及认知功能障碍患者Hcy水平更高（P〈0．05）；②T2DM认知功能障碍与年龄、Hcy、糖化血红蛋白、尿微量白蛋白、尿总蛋白及高血压、脑梗死、冠心痛病史、合并神经病变相关（P〈0．05，P〈0．01）。【结论】高Hcy血症与T2DM患者认知功能障碍密切相关，预防糖尿病认知功能障碍需干预多种危险因素。

Relationship Between Cognitive Disorder and Homocysteine in Patients with Type 2 Diabetes Mellitus and Analysis of the Risk Factors

[Objective]To explore observe the relationship between cognitive disorder and homocysteine （Hcy） in type 2 diabetes mellitus（T2DM） and the analysis of the risk factors of cognitive disorder. [Methods] Blood glucose, blood lipids, BUN, Cr, Hcy and many other indicators were compared between 185 T2DM patients and 80 healthy controls. T2DM patients were tested with mini-mental state examination （MMSE）. The relationship between the above indexes and cognitive disorder was analyzed. [Results] The level of Hcy in T2DM patients was obviously higher than that in control group, and patients with hypertension, cerebral infarction, coronary heart disease and cognitive disorder had high level of Hcy（ P 〈0.05）. The cognitive disorder of T2DM patients was correlated with age, Hcy, HBAlc, urinary microalbumin, urine total protein, the history of hypertension, cerebral infarction, and coronary heart disease and the complication with neuropathy（ P 〈0.05, P 〈0.01）. [Conclusion] Hyperhomocysteinaemia is closely related to cognitive disorder in T2DM patients. The prevention of cognitive disorder of diabetes mellitus needs the intervention of multiple risk factors.