14—3—3Sigma蛋白质在肺腺癌中的表达及意义

【目的】探讨14—3—3Sigma蛋白质在肺腺癌组织中的表达及意义。【方法】采用免疫组化方法检测正常肺组织、炎性假瘤、肺腺癌组织和转移淋巴结标本中14—3—3Sigma蛋白质的表达，分析其临床意义。【结果】14—3—3Sigma蛋白的表达主要定位于细胞膜，部分位于胞浆，14—3—3Sigma蛋白在正常肺组织和炎性假瘤不表达或存在弱阳性表达，而在肺腺癌组织和转移淋巴结中存在中到强阳性表达，14—3—3Sigma蛋白在正常肺组织、炎性假瘤、肺腺癌组织和转移淋巴结中表达有显著差异性（PdO．05），但14—3—3Sigma蛋白在正常肺组织和炎性假瘤比较无统计学意义（P〉O．05）。【结论]14—3—3Sigma蛋白质可能与肺腺癌的发生、发展和转移有关。

Expression of 14-3-3 Sigma Protein in Human Lung Adenocarcinoma

[Objective] To explore the expression of 14-3-3 Sigma protein in lung adenocarcinoma and its clinical significance. [Methods] Immunohistochemistry method was used to examine the expression of 14-3-3 Sigma protein in normal lung tissues, pulmonary inflammatory pseudotumor, tung adenocarcinoma and lymph node metastasis tissues. Clinical significance was analyzed. [Results]The expression of 14-3-3 Sigma protein mainly located in cell membrane and partly located in cytoplasm. Normal lung tissues and inflammatory pseud- otumor had no or weak expression of 14-3-3 Sigma, but lung adenocarcinoma and lymph node metastasis tis- sues had strongly positive expression of 14-3-3 Sigma. There were significant differences in the expression of 14 3-3 Sigma among normal lung tissues, pulmonary inflammatory pseudotumor, lung adenocarcinoma and lymph node metastasis tissues（ P d0.05）, but there was no significant difference in the expression of 14-3-3 Sigma protein between normal lung tissues and inflammatory pseudotumor （ P 〉 0. 05）. [Conclusion]The 14-3-3 Sigma protein may be involved in the occurrence, development and metastasis of lung adenocarcinoma.