全身 STIR 与全身 DWI 检出前列腺癌、乳腺癌及多发骨髓瘤骨转移病灶能力差异比较研究

[目的]比较全身反转恢复成像（STIR）和全身弥散加权成像（DWI）在全身骨转移瘤评估上相对信号强度的差异。[方法]44例恶性肿瘤患者均行全身 MRI扫描，包括冠状位 T1WI ，STIR 及 DWI（b＝800）。每次扫描，经T1 WI确认最多4个最大的病灶，定量计算每一病灶的平均信号强度与背景的比值，对于该感兴趣区（ROI）的STIR和DWI的病灶/背景信号强度进一步进行比较。[结果]有92％（22/24）前列腺癌患者DWI的病灶/背景比值高于STIR（3．91 vs 2．31），差异有显著性（ P ＜0．01）。有86％（6/7）多发骨髓瘤的患者，DWI的病灶/背景高于STIR（7．59 vs 3．70），差异有显著性（ P ＜0．05）。有69％（9/13）乳癌患者， STIR和DWI的病灶/背景接近（4．13 vs 4．26，P ＞0．05）。[结论]通过测定肿瘤/背景信号比值来研究骨转移瘤MRI成像方法表明，对于前列腺癌和多发骨髓瘤病患而言，DWI在b值＝800时较STIR具有更高的显示能力。全身DWI应该用于此类病变的检查当中。

Comparative Study on Whole Body STIR vs DWI for the Detection of Bone Metastasis Ability of Prostate,Breast and Multiple Myeloma

[Objective] To compare the difference of the relative signal intensity of whole body bone metas-tasis assessed by whole body short time inversion recovery （STIR） vs diffusion-weighted MRI （DWI） .[Meth-ods] All 44 cases received whole-body MRI scans including coronal T1 weighted（T1WI） ,STIR and DWI（b=800） .On each scan ,at most 4 largest bone lesions were identified on T1WI .The ratio of mean signal intensity to background signal intensity of each lesion was calculated .Lesion/background signal intensity ratio on STIR and DWI in the region of interest（ROI） was further compared .[Results] Signal/background ratio on DWI of 22 out of 24 patients with prostate cancer was higher than that on STIR （3 .91 vs 2 .31 ,P ＆lt;0 .01） .Signal/background ratio on DWI of 6 out of patients with multiple myeloma was higher （7 .59 vs 3 .70 ,P ＆lt; 0 .05） . Signal/background ratio on DWI of 13 patients with breast cancer was similar to that on DWI （4 .13 vs 4 .26 ,P＆gt;0 .05） .[Conclusion]MRI method for bone metastasis by measuring tumor/background signal intensity ratio shows that DWI（b=800） has higher conspicuity than STIR .Whole body DWI should be used in the detection of the lesions .