The evolution of Epstein-Barr virus inferred from the conservation and mutation of the virus glycoprotein gp350/220 gene |
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Authors: | Asako Kawaguchi Kyosuke Kanai Yukio Satoh Chizu Touge Keiko Nagata Takeshi Sairenji and Yoshitsugu Inoue |
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Institution: | (1) Divison of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, Yonago, Japan;(2) Division of Biosignaling, Department of Biomedical Sciences, School of Life Science, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan |
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Abstract: | To study variations of Epstein-Barr virus (EBV), we analyzed the gp350/220 gene for several cell lines and Japanese wild isolates
using direct sequencing. The N-terminal region was highly conserved in all EBVs except for Jijoye/P3HR-1 and a few isolates.
The variation of the region coincided with EBV types A and B (also referred to as types 1 and 2) and were, respectively, designated
as the types a and b. The type A/a was detected in most Japanese cell lines and wild isolates, and was classified as China1
type with latent membrane protein (LMP) 1 gene. The type B/b was detected in only a few wild isolates with the Med and China2
types. The C-terminus had more diversity than the N-terminus and lacked the divergence between types A/a and B/b. The phylogenetic
analyses of the gp350/220 and LMP1 genes may suggest a mode of EBV evolution into types A/a and B/b and then to LMP1 subtypes. |
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Keywords: | Epstein-Barr virus (EBV) Gene mutation gp350/220 gene LMP1 gene Phylogenetic analysis Virus evolution |
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