| 一氧化氮自由基与铜、铁离子在细胞恶性变中的协同作用 |
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| 引用本文： | 俸家富,李少林.一氧化氮自由基与铜、铁离子在细胞恶性变中的协同作用[J].实用临床医学(江西),2002,3(1):9-11. |
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| 作者姓名： | 俸家富 李少林 |
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| 作者单位： | 四川省自贡市第三人民医院 四川自贡643020
(俸家富)，重庆医科大学基础医学院 重庆400016(李少林) |
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| 摘 要： | 目的 :研究一氧化氮自由基和铜、铁离子在细胞恶性变中的协同作用。方法 :测定了 111例癌症病人和 36例健康人血清中醛基丙二醛 (MDA)浓度 (以此作为脂质过氧化指标 )、铜、铁离子浓度。结果 :癌症患者脂质过氧化水平 (测定MDA)明显高于健康人 (P <0 .0 0 1)。同健康对照组比较 ,血清铜水平明显增高 (P <0 .0 0 1) ,但铁水平无显著变化。结论 :一氧化氮自由基和铜、铁离子可促进反应性氧类 (ROS)产生 ,引发和 /或加速正常细胞恶性化
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| 关 键 词： | 癌症 一氧化氮自由基 铜离子 铁离子 |
| 文章编号： | 1009-8194(2002)01-0009-03 |
| 修稿时间： | 2001年7月23日 |
Synergism of Ions of Cu2+ and Fe3+ and NO Free Radical in Cell Malignant Transformation |
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| Feng Jia fu ,Li Shao lin.Synergism of Ions of Cu2+ and Fe3+ and NO Free Radical in Cell Malignant Transformation[J].Practical Clinical Medicine,2002,3(1):9-11. |
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| Authors: | Feng Jia fu Li Shao lin |
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| Institution: | Feng Jia fu 1,Li Shao lin 2 |
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| Abstract: | Objective:To study the synergism of ions of Cu 2 and Fe 3 and NO free radical in cell malignant transformation. Methods: The concentrations of malondialdehyde (MDA) and trace elements(copper and iron) were detected in 111 patients with cancers. Meanwhile the levels of serum nitric oxide were also measured. Thirty-six healthy persons took part in as controls. Results: lipid preoccupation (measured as MDA) was significantly increased in the patients than that in the control group ( P <0.01). As compared to the healthy controls, serum copper level in the patients was significantly increased ( P <0.01). The concentration of iron, however, remained unchanged. Conclusion: Ions of Cu 2 and Fe 3 as well as NO free radical may increase ROS production, which can trigger and/or promote the malignant transformation of normal cell. |
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| Keywords: | cancer nitric oxide free radical Cu 2 Fe 3 |
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