cyclinB1、p34cdc2在卵巢上皮性肿瘤中的表达及临床意义

目的探讨细胞周期调控因子cyclinB1、p34cdc2在卵巢肿瘤发生、发展及预后中的作用。方法应用免疫组化SP法对正常卵巢、卵巢良性上皮性肿瘤及恶性肿瘤中cyclinB1、p34cdc2的表达进行检测。结果cy-clinB1和p34cdc2在正常卵巢、良性肿瘤和恶性肿瘤中的阳性表达呈递增趋势,在恶性肿瘤的阳性表达率显著高于正常卵巢和良性肿瘤(P<0.05);并且cyclinB1和p34cdc2的表达与肿瘤的分化程度、临床分期及预后明显相关(P<0.05)。结论cyclinB1和p34cdc2在卵巢肿瘤的进展、诊断和判断预后方面有一定的意义。

Expression and significance of cyclinB1 and p34cdc2 in epithelial ovarian tumor

Objective: To study the role of cyclinB1 and p34cdc2 in epithelial ovarian tumor. Methods: Immunohistochemistry was used to examine the expression of cyclinB1 and p34cdc2 in normal ovay,benign epithelial ovarian tumor and malignante ovarian tumor. Results: The expression of cyclinB1 and p34cdc2 increased with normal ovay,benign epithelial ovarian tumor and malignante tumor,the expression rate in malignancy was remarkable higher than in normal ovay and benign epithelial ovarian tumor(P<0.05);and significant correlation was found in the positive expression of cyclinB1 and p34cdc2 in grading,staging and prognosis(P<0.05). Conclusion: The expression of cyclinB1 and p34cdc2 is positively correlated with development and prognosis of ovarian tumor.