血流灰阶显像技术评价兔腹主动脉粥样硬化的实验研究

目的 探讨超声血流灰阶显像(BFI)技术对兔腹主动脉粥样硬化的诊断价值.方法 兔16只,高脂饮食喂养12周,建立兔腹主动脉粥样硬化模型.于实验前及实验后第4,8,12周末进行超声检查,检查兔腹主动脉前壁及后壁内-中膜厚度,观察斑块形成情况;对比启用BFI技术前后动脉内膜及斑块的显像差异,应用超声组织定征技术对内膜及斑块灰阶进行定量分析,并与病理检查对照.结果 使用BFI技术后,动脉内膜回声明显增强,部分斑块回声增强,且新发现4例软斑块.结论 BFI技术能显著提高动脉粥样硬化早期诊断的灵敏度和斑块的检出率.

Evaluation of the abdominal aortic atherosclerosis with blood flow image technique in rabbits

Objective To evaluate the value of the blood flow image(BFI)technique in the diagnosis of abdominal aortic atherosclerosis.Methods Sixteen rabbits were fed with high cholesterol diet for 12 weeks to induce atherosclerosis.The intimal-me- dial thickness(IMT)of abdominal aortic anterior wall,posterior wall and the plaque were measured with ultrasound before and at the 4th,8th and 12th weekend of the experiment.The images of IMT and plaque before and after BFI technique used were analyzed.The echo intensity of the images of IMT and plaque was determined with ultrasonic tissue characterization and the results were compared with the pathologic outcomes.Results The echo intensity of IMT and plaques increased significantly after BFI technique used.Besides, four new plaques were found.Conclusion BFI technique can increase the sensitivity of early diagnosis of athemsclerosis and improve the detection rate of plaque in the early stage.