Serum fluoride levels in morbidly obese patients: enflurane compared with isoflurane anaesthesia |
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| Authors: | P. J. STRUBE G. H. HULANDS M. J. HALSEY |
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| Affiliation: | P.J. Strube, FFARCS, Senior Registrar, G.H. Hulands, FFARCS, Consultant, Northwick Park Hospital, Watford Road, Harrow. Middlesex HAI 3UJ;M.J. Halsey, MA, DPhil, Head of HPNS Group, Division of Anaesthesia, Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ. |
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| Abstract: | Obese patients are known to metabolise anaesthetic agents more than patients of normal weight. The extent of this was investigated by the measurement of serum fluoride concentrations in 10 morbidly obese patients undergoing gastroplasty. Five were allocated to receive enflurane and five to receive isoflurane supplemented anaesthesia. The mean peak serum fluoride concentrations after enflurane anaesthesia were greater (22.7 mumol/litre, SE 2.9) than after isoflurane anaesthesia (6.5 mumol/litre, SE 0.6). The mechanisms and implications of this finding are discussed. |
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| Keywords: | Complications obesity Metabolism anaesthetics |
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