苦瓜降糖胶囊对老年2型糖尿病患者血糖、血脂的影响

背景苦瓜属植物提取物有降糖效果是已被证实的,而其是否有调脂作用还需进一步研究.目的评价苦瓜降糖胶囊对老年2型糖尿病的降糖及调脂作用.设计前后对照试验.地点、对象和方法研究对象为2003- 03收集的 35例男性 2型糖尿病患者,年龄 70～ 86岁,平均( 77± 5)岁.纳入研究对象均为军队干休所离退休干部;既往均明确诊断为2型糖尿病,即符合 1985年世界卫生组织 2型糖尿病诊断标准;所有患者 1个月未用过胰岛素及口服降糖药物.排除患有其他严重的躯体性疾病;有精神疾病或精神疾病家族史;有严重智力或认知障碍患者.对35例患者投入的药物为本院制备的苦瓜降糖胶囊.每例患者均在疗程前后立即检测空腹血糖、餐后2 h血糖、糖化血红蛋白和血脂.血糖测定为酶试剂法.糖化血红蛋白采用微柱法.总胆固醇、三酰甘油、高密度脂蛋白胆固醇均用酶法.主要观察指标用药前后的血糖、血脂的变化.结果采用苦瓜降糖胶囊治疗后患者空腹血糖,餐后2 h血糖及糖化血红蛋白 [(5.02± 1.67) ,(9.70± 3.44)mmol/L,(5.79± 1.18)% ]均有较治疗前[(7.59± 1.83) ,(12.63± 3.65)mmol/L,(6.33± 1.28)% ]明显下降( t=14.496, 8.493, 4.644,P《 0.01).总有效率分别为 94%( 33/35), 80%( 28/35), 80%( 28/35).治疗后胆固醇、三酰甘油有明显下降(t=12.400, 7.487, P《 0.01),高密度脂蛋白胆固醇有明显上升( t=6.312, P《0.01).总有效率分别为 71%( 25/35), 77%( 27/35), 66%( 23/35).结论苦瓜降糖胶囊对2型糖尿病,能有效地控制和降低血糖及调脂作用.

Effects of kugua jiangtang capsule on blood sugar and lipid in patients with type 2 diabetes

BACKGROUND:The extract of Momordica charantia plant has been verified to act on reducing sugar,but it is required the further study on whether it acts on regulating lipid. OBJECTIVE:To evaluate the function of kugua jiangtang capsule(Capsule) on reducing sugar and regulating lipid in patients with type 2 diabetes. DESIGN:Controlled trial design. SETTING,PARTICIPANTS and METHODS:A total of 35 male patients with diabetes II,aged varied from 70 to 86 years,at the average of( 77± 5) years were collected in March 2003.All the patients were the retired military officers and diagnosed definitely as type 2 diabetes according to the 85' WHO Diagnosis Standard of Type 2 diabetes.All the patients had not used insulin and taken drugs for lowing sugar orally.The severe physical disorders,mental disorders,family mental disorders and severe intelligent or recognition disturbance were excluded.The Capsule prepared by the Hospital was prescribed for 35 patients.Each patients checked fasting plasma glucose(FPG),2 hours plasma glucose(PG),and blood lipid immediately before and after treating course.Blood sugar was tested by enzyme reagent method,glycosylated hemoglobin(HbA1C) by Micro Adsorption Column,total cholesterol(Tch),triglycerinum(TG) and high density lipoprotein-cholesterol(HDL-C) by enzyme reagent. MAIN OUTCOME MEASURES:Changes in blood sugar and lipid before and after medication. RESULTS:After treated with the Capsule,the results of FPG,2 hours PG and HbA1C[(5.02± 1.67) mmol/L,(9.70± 3.44)mmol/L,(5.79± 1.18)% ] were all remarkably reduced compared with the results[(7.59± 1.83) mmol/L,(12.63± 3.65)mmol/L,(6.33± 1.28)% ] before treatment( t=14.496, 8.493, 4.644, P< 0.01) . Total effective rates were 94% (33/35),80% (28/35),80% (28/35) respectively.After treatment,cholesterol and TG were remarkably reduced( t=12.400, 7.487, P < 0.01) and HDL-C remarkably increased( t=6.312, P< 0.01) .Total effective rates were 71% (25/35), 77%( 27/35), 66%( 23/35) successively. CONCLUSION:The capsule acts effectively on controlling and reducing blood sugar and lipid in type 2 diabetes.