| 妊娠期肝内胆汁淤积症的药物治疗对围生儿预后的影响 |
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| 引用本文： | 徐晓燕,陈汉平. 妊娠期肝内胆汁淤积症的药物治疗对围生儿预后的影响[J]. 华中医学杂志, 2003, 27(2): 87-88 |
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| 作者姓名： | 徐晓燕 陈汉平 |
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| 作者单位： | 430030,武汉,华中科技大学同济医学院附属同济医院 |
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| 摘 要： | 目的 评价妊娠期肝内胆汁淤积症(ICP)的药物治疗对围生儿预后的影响。方法 36例ICP患者分为3组，A组行熊去氧胆酸(UDCA)治疗；B组行地塞米松(DX)治疗；C组联用葡萄糖、维生素C、肌苷和苯巴比妥治疗。分别与末治疗组(D组，35例)进行分析，观察其对围生儿预后的影内。结果 A、B两组的胎儿窘迫、早产、羊水粪染的发生率明显减少(P＜0．05)，且对母儿无毒副作用。结论 UDCA和DX是治疗ICP安全有效的药物，能改善围生儿的预后。
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| 关 键 词： | 妊娠期 肝内胆汁淤积症 药物治疗 围生儿 预后 影响 |
| 修稿时间： | 2002-12-01 |
Effect of medical therapy for intrahepatic cholestasis of pregnancy on the perinatal prognosis |
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| Xu Xiaoyan,Chen Hanping. Tongji Mdical College,Tongji Hospital,Huazhong Unviversity of Science and Technology,Wuhan. Effect of medical therapy for intrahepatic cholestasis of pregnancy on the perinatal prognosis[J]. Central China Medical Journal, 2003, 27(2): 87-88 |
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| Authors: | Xu Xiaoyan Chen Hanping. Tongji Mdical College Tongji Hospital Huazhong Unviversity of Science Technology Wuhan |
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| Affiliation: | Xu Xiaoyan,Chen Hanping. Tongji Mdical College,Tongji Hospital,Huazhong Unviversity of Science and Technology,Wuhan 430030 |
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| Abstract: | Objective To evaluate the effect of medical therapy for intrahepatic cholestasis of pregnancy (ICP) on the perinatal prognosis. Methods Seventy-one cases of ICP were divided into 4 groups: group A subject to ursodeoxycholic acid (UDCA), group B to desamethasone (DX), group to a combination of 10% glucose, Vit C, inosine and phenobarbital, and group D as control group. Results The occurrence of fetal distress, preterm labor and meconium staining in amniotic fluid was lower in the patients receiving UDCA and DX (P<0.05). No adverse effects were detected in the mothers of in their babies. Conclusion UDCA and DX are efective and safe in the patients with ICP. They can improve the perinatal prognosis. |
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| Keywords: | Intrahepatic cholestasis of pregnancy Medical Therapy Perinatal prognosis |
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