| 非产毒艰难梭菌对艰难梭菌感染BALB/c小鼠的防治作用 |
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| 引用本文： | 王祥,傅思武.非产毒艰难梭菌对艰难梭菌感染BALB/c小鼠的防治作用[J].兰州医学院学报,2009,35(3):35-37. |
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| 作者姓名： | 王祥 傅思武 |
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| 作者单位： | 王祥,WANG Xiang(兰州大学第二医院消化内科,甘肃,兰州,730030);傅思武,Fu Si-wu(西北民族大学,医学院,甘肃,兰州,730030) |
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| 摘 要： | 目的观察非产毒艰难梭菌对艰难梭菌感染的防治效果。方法用艰难梭菌产毒株人工感染BALB/c小鼠,感染前后分别用非产毒艰难梭菌进行预防与治疗,以小鼠的死亡数、盲肠内容物上清液的细胞毒性和盲肠黏膜的病理变化为观察指标,判断非产毒艰难梭菌对艰难梭菌感染的防治效果。结果非产毒艰难梭菌不能预防艰难梭菌的感染,但在艰难梭菌感染后能明显降低盲肠黏膜的病理损伤。结论非产毒艰难梭菌对感染艰难梭菌的BALB/c小鼠有一定的治疗作用。
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| 关 键 词： | 非产毒艰难梭菌 艰难梭菌 BALB/c小鼠 感染 |
Preventive and treatment of nontoxigenic Clostridium difficil to toxigenic Clostridium difficile infection of BALB/c mice |
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| WANG Xiang,Fu Si-wu.Preventive and treatment of nontoxigenic Clostridium difficil to toxigenic Clostridium difficile infection of BALB/c mice[J].Journal of Lanzhou Medical College,2009,35(3):35-37. |
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| Authors: | WANG Xiang Fu Si-wu |
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| Institution: | WANG Xiang, Fu Si-wu(1 Department of Gastroenterology, Second Hospital of Lanzhou University, Lanzhou 730030, China, 2. Medical College, Northwest University for Nationalities, Lanzhou 730030, China) |
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| Abstract: | Objective To observe the prevention and treatment effect of nontoxigenic Clostridium difficile to protect BALB/c mice against intestinal infection caused by toxigenic Clostridium dificile. Methods Nontoxigenic Clostridium difficile was used before and after infection with toxigenic Clostridium difficile in BLAB/c mice. The mortality of mice, quantity of cytotoxin produced in cecal and histopathogencal destroy were observed. Results There were no bacterio- prophylaxis using and nontoxigenic Clostridium difficile against infection by toxigenic Clostridium difficile, but the enterocolitis of the caecum after the mice was pre-infected with toxigenic Clostrid- ium difficile. Conclusion The study confirms the protective effect and nontoxigenic Clostridium difficile treatment on BLAB/c mice pre-infected with toxinogenic Clostridiurn difficile. |
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| Keywords: | nontoxigenic Clostridium difficile Clostridium difficile BALB/c mice infection |
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