参麦注射液防治含奥沙利铂化疗方案所致神经毒性效果的临床观察

目的:观察参麦注射液防治含奥沙利铂化疗方案所致神经毒性的效果。方法:将96例应用含奥沙利铂化疗方案化疗的胃癌或大肠癌患者随机分为2组,试验组46例,对照组50例。试验组化疗前一天开始将参麦注射液50 mL加入5%葡萄糖注射液200 mL中静脉滴注,qd,连用14 d为1个周期。对照组不加用参麦注射液,单纯化疗。4个化疗周期(每个化疗周期21 d)后评价疗效,观察神经毒性反应的变化,并测定周围神经功能。结果:试验组神经毒性发生率32.6%(15/46),对照组为72.0%(36/50),2组比较差异有统计学意义(P<0.05)。周围神经功能测定,试验组和对照组腓神经感觉神经传导速度(SCV)分别为(40.5±3.2)m.s-1和(34.3±3.1)m.s-1,感觉神经动作电位波幅分别为(9.0±3.8)μV和(7.2±3.3)μV,2组比较差异有显著性(P<0.05)。结论:参麦注射液对含奥沙利铂化疗方案所致的神经毒性具有明显的防治作用。

Clinical observation on the efficacy of Shenmai injection in prevention and treatment of neurotoxicity induced by oxaliplatin-containing chemotherapy regimen

OBJECTIVE To study the curative effect of Shenmai injection for prevention of the neurotoxicity caused by chemotherapy drug including oxaliplatin.METHODS The investigation was a prospective study of 96 patients of cancer of stomach and cancer of colon with a need for chemotherapy drug including oxaliplatin.The curative group(46 patients)began to use Shenmai injection(50ml)put in 5%GS one day before chemotherapy,1 time/d,d1-14,ivgtt.So did the control group(50patients),except Shenmai injection.To observe the variation of neurotoxicity and determine nerve peronaeus function after 4 cycles.RESULTS Incidence of neurotoxicity in the curative group was 32.6%(15/46),the other 72.0%(36/50)(P<0.05).The curative group was better than the other,which was also supported by nerve peronaeus function(P<0.05).that the sensory nerves conduction velocity(SCV)of curative group and control group was(40.5±3.2) m·s-1 and(34.3±3.1) m·s-1 respectively;the action potential amplitude of sensory nerves(9.0±3.8) μV and(7.2±3.3) μV.CONCLUSION It was certained that Shenmai injection was effective in preventing the neurotoxicity caused by chemotherapy drug including oxaliplatin.