2006-2010年陕西省干部群体脂肪肝流行病学调查

目的:调查陕西省干部群体脂肪肝流行病学,为预防保健和治疗提供依据.方法:整群抽取2006-2010年在陕西省人民医院干部体检中心进行体检的资料保存完整的厅级干部体检资料,进行脂肪肝患病率和危险因素的logistic回归分析.结果:研究对象脂肪肝患病率40.25%,5年患病率呈逐年增高趋势,差异有统计学意义(P<0.01).单因素分析显示脂肪肝与年龄、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白(high density lipoprotein,HDL-C)、血尿酸、空腹血糖、体质量变化、家族高血脂史、日坐位时间、家务劳动、周锻炼次数、次锻炼时间、体质量指数、腹围14个因素相关;经多因素回归分析,危险因素依次为甘油三酯(OR:1.92)、空腹血糖(OR:1.172)、体质量指数(OR:1.149)、腹围(OR:1.140),日坐位时间与脂肪肝呈负相关(OR:0.786,95%CI:0.625-0.989).

An epidemiological investigation of the prevalence and risk factors for fatty liver in the cadre population in Shaanxi Province from 2006 to 2010

AIM:To study the epidemiology of fatty liver in the cadre group in Shaanxi Province to provide a basis for prevention and treatment of this disease.METHODS:The physical examination data for the cadre group in Shaanxi Province from 2006 to 2010 that were preserved in Shaanxi Provincial People’s Hospital were collected by cluster sampling.The prevalence of fatty liver was calculated,and its risk factors were analyzed by logistic regression analysis.RESULTS:The prevalence of fatty liver in the investigated population was 40.25%,and the annual prevalence rose gradually over the fiveyear period.Univariate analysis indicated that the development of fatty liver was significantly associated with age,total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL-C),blood uric acid,fasting blood glucose,weight change,family history of high blood lipid,day sitting time,housework,weeks of exercise frequency,exercise time,body mass index,and abdominal circumference.Multiple logistic regression analysis revealed that the risk factors for fatty liver were TG(OR:1.92),fasting blood glucose(OR:1.172),body mass index(OR:1.149),and abdominal circumference(OR:1.140).Day sitting time had a negative correlation with the risk of fatty liver(OR:0.786,95% CI:0.625-0.989).CONCLUSION:The prevalence of fatty liver in subjects investigated rose annually in the cadre population in Shaanxi Province from 2006 to 2010.Fatty liver is closely related with TG,fasting blood glucose,body mass index and abdominal circumference.Close monitoring and effective measures should be carried out in people at higher risk for fatty liver.