唑来膦酸联合化疗治疗实体瘤骨转移临床观察

目的:探讨唑来膦酸联合化疗治疗实体瘤骨转移的临床疗效。方法:102例实体瘤患者随机分为治疗组和对照组各51例,对照组予常规化疗,治疗组加用唑来膦酸静滴,评价止痛、骨转移灶修复及生活质量改善疗效,测定TNF-α、IL-6、MMP-2、MMP-9和血钙含量,记录治疗过程中的不良反应。结果:治疗组止痛有效率为86.3%,骨转移灶修复有效率为54.9%,生活质量改善有效率为72.5%,均明显优于对照组(P<0.05或P<0.01);治疗组治疗后TNF-α、IL-6、MMP-2、MMP-9和血钙含量均明显下降(P<0.01),且均明显优于对照组(P<0.01);与对照组相比,主要不良反应是一过性发热(P<0.01)。结论:唑来膦酸联合化疗治疗实体瘤骨转移疗效肯定,不良反应可耐受。

Effect of zoledronic acid combined with chemotherapy on the treatment of bone metastasis

OBJECTIVE To explore the clinical effects of zoledronic acid combined with chemotherapy on the treatment of bone metastasis.METHODS 102 patients were randomly divided into two groups.The control group received chemotherapy,the study group received zoledronic acid additionally.The analgesic effects,restoration effect of bone metastasis,life quality improvement effects were evaluated;the level of TNF-α,IL-6,MMP-2,MMP-9 and calcium were determined;the toxicity reaction were recorded.RESULTS For the study group,the analgesic efficiency was 86.3%,the restoration efficiency of bone metastasis was 54.9%,the life quality improvement efficiency was 72.5%,which were all better than that of control group(P<0.05 or P<0.01);the level of TNF-α,IL-6,MMP-2,MMP-9 and calcium were all decreased(P<0.01),and were all better than that of control group(P<0.01);the main toxicity reaction was ephemeral fever(P<0.01).CONCLUSION Zoledronic acid with combined chemotherapy was effective and well tolerated treatment for patients with bone metastasis.