Heat shock proteins and drug resistance |
| |
Authors: | Suzanne A W Fuqua Steffi Oesterreich Susan G Hilsenbeck Daniel D Von Hoff John Eckardt C Kent Osborne |
| |
Institution: | (1) Department of Medicine, Division of Medical Oncology, University of Texas Health Science Center, 7703 Floyd Curl Drive, 78284-7884 San Antonio, Texas, USA;(2) Cancer Therapy and Research Center, 78224 San Antonio, Texas, USA |
| |
Abstract: | Summary Heat shock proteins (hsp's) are induced in cells when exposed to different environmental stressful conditions. We have found that breast cancer cells sometimes express high levels of several hsp's, which may both augment the aggressiveness of these tumors and make them more resistant to treatment. We have shown that hsp70 is an ominous prognostic sign as detected by Western blot assays in node-negative breast tumors, and that hsp27 increases specific resistance to doxorubicin in breast cancer cell lines. These findings have direct clinical application, and suggest that modulating hsp expression may be a therapeutic target for reversal of hsp-associated detrimental cellular effects. |
| |
Keywords: | doxorubicin drug resistance heat shock hsp27 hsp70 prognosis stress response |
本文献已被 SpringerLink 等数据库收录! |
|