左归饮对老年小鼠抗氧化作用及胸腺脾脏指数的影响

目的:从抗氧化作用及免疫器官指数角度探讨左归饮延缓衰老的作用机理。方法:以5.5 g/(kg.d)浓缩左归饮煎液自由饮75 d,并以老年小鼠作对照,观察左归饮对老年小鼠血清丙二醛(MDA)、超氧化物歧化酶(SOD)、总抗氧化能力(T-AOC)及胸腺指数、脾指数的影响。结果:老年小鼠与青年小鼠比较MDA含量明显升高,SOD活性、T-AOC、胸腺指数和脾指数显著降低。应用左归饮则使老年小鼠上述指标明显恢复,且差异显著。结论:左归饮能增强老年小鼠的抗氧化能力,减少自由基对细胞膜的损伤,抑制免疫器官的退化和萎缩,起到延缓衰老的作用。

Influence of Zuoguiyin on Antioxiadation in Blood Thymus and Spleen Index of Senile Mice

Objective:To explore the free radical mechanism of Zuoguiyin(ZGY) in delaying senility.Methods:After the ZGY group of mice had freely drunk the concentrated decoction for 75 days,and compared with the old control group,we observed the effect on the indices of thymus index,spleen index,the contents of MDA,the activities of SOD and T-AOC of serum.Results:Compared to the young control group,the old control group showed significant increase in the contents of MDA in blood,significant decrease in the activities of SOD,T-AOC in blood,and decrease in thymus index and spleen index.The ZGY group showed significant improvement for the above parameters compared with the old control group.The differences were statistically significant.Conclusion:Zuoguiyin could delay the senility,which might be related with increasing antioxdation and thymus index and spleen index,meanwhile,reducing the damage of free radical to cell membrane.