Embryos cultured in vitro with multinucleated blastomeres have poor implantation potential in human in-vitro fertilization and intracytoplasmic sperm injection |
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Authors: | Pelinck MJ; De Vos M; Dekens M; Van der Elst J; De Sutter P; Dhont M |
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Institution: | Infertility Centre, Department of Obstetrics and Gynaecology, University Hospital, Ghent, Belgium. |
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Abstract: | The aim of the present study was to investigate pregnancy rates ensuing
from transfer of embryos with multinucleated blastomeres. In our in- vitro
fertilization (IVF)/intracytoplasmic sperm injection (ICSI) programme, 1735
embryo transfers were performed from January 1, 1995 to August 31, 1996. In
136 of these transfers at least one embryo with one or more multinucleated
blastomeres was present per transfer (study group). For each of these 136
transfers, two matched controls with transfer of exclusively mononucleated
embryos were selected (control group). Matching was carried out according
to age, method of fertilization (IVF or ICSI), number of transferred
embryos and quality score of transferred embryos. In the study group, there
were eight transfers of exclusively multinucleated embryos from which one
pregnancy ensued and 128 transfers in which multinucleated and
mononucleated embryos were transferred together leading to 23 pregnancies.
The overall clinical pregnancy rate per transfer was 16.9% in the study
group versus 28.7% in the control group (P = 0.01). The ongoing pregnancy
rate per transfer was 13.2% in the study group versus 23.2% in the control
group (P = 0.03). The implantation rate per transferred embryo was 6.0% in
the study group versus 11.3% in the control group (P = 0.003). This study
shows that embryos with one or more multinucleated blastomeres have a
poorer implantation potential than embryos with mononucleated blastomeres.
Transfer of embryos with multinucleated blastomeres should hence only be
considered when insufficient numbers of embryos with only mononucleated
blastomeres are present.
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