| 胸苷磷酸化酶检测在乳腺癌病人个体化化疗中的应用 |
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| 引用本文： | 吴常青,谷俊朝. 胸苷磷酸化酶检测在乳腺癌病人个体化化疗中的应用[J]. 现代肿瘤医学, 2006, 14(8): 957-958 |
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| 作者姓名： | 吴常青 谷俊朝 |
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| 作者单位： | 1. 河南省平舆县中心医院,河南,平舆,463400
2. 首都医科大学附属北京友谊医院普外科,北京,100020 |
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| 摘 要： | 目的:探讨胸苷磷酸化酶(thym id ine phosphorylase TP)检测在乳腺癌病人化疗中的应用价值。方法:2003年3月~2005年2月对85例可手术女性乳腺癌病人采用CTX 卡培他滨方案的新辅化疗3个周期,化疗结束后评估临床疗效并行乳腺癌根治术,标本行TP检测,分析化疗疗效与TP表达的关系。结果:TP阳性者64例,化疗有效率71.78%;TP阴性者21例,化疗有效率28.57%(P<0.01)。结论:TP检测对乳腺癌病人个体化化疗具有指导性意义。
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| 关 键 词： | 乳腺肿瘤 化疗 胸苷磷酸化酶 |
| 文章编号： | 1672-4992-（2006）08-0957-02 |
| 收稿时间： | 2005-10-24 |
| 修稿时间： | 2006-02-21 |
Application of thymidine phorylase test in tailoredua chemotherapy in the patients with breast cancer |
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| WU Chang-qing,GU Jun-chao. Application of thymidine phorylase test in tailoredua chemotherapy in the patients with breast cancer[J]. Journal of Modern Oncology, 2006, 14(8): 957-958 |
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| Authors: | WU Chang-qing GU Jun-chao |
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| Abstract: | Objective:To investigate the correlation between thymidine phosphrylase(TP) expression and response to chemotherapy in patients with breast cancer.Methods: From March 2003 to February 2005,85 cases of operable primary breast cancer patients had received chemotherapy with ctx xeloda regimen for 3 cycles.Clinic effect was evalauated and operation was performed after chemotherapy.Specimen were examined by TP test,to investigate the correlation between TP expression and response to chemotherapy.Results: Sixty four cases were TP positive,chemotherapy effectivre rate was 71.78%;21 cases TP negative,chemotherapy effective rate was 28.75%(P<0.01).Conclusion: The expression of TP can be an important marker in selecting chemotherapy regimen and predicting the efficacy of chemotherapy for breast cancer patients. |
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| Keywords: | breast neoplasms chemotherapy thymidine phosphorylase |
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