Hyperinsulinemia negatively affects the association between insulin resistance and blood pressure |
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| Affiliation: | 1. Department of Traffic Management Engineering, Zhejiang Police College, No. 555 Binwen Road, Binjiang District, Hangzhou, China;2. Department of Endocrinology, Punan Hospital of Pudong New District, No. 279 Linyi Road, Pudong, Shanghai, 200336, China;3. Hangzhou Aeronautical Sanatorium for Special Service of China Air Force, No. 27, Yang Gong Di, Xihu District, Hangzhou, Zhejiang, 310007, China;1. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China;2. Department of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China;3. Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China;1. Pudong New Aera Gaodong Community Health Service Center, Shanghai, China;2. Fudan University School of Public Health, Shanghai, China;3. Qingpu District Center for Disease Control and Prevention, Shanghai, China;1. Department of Cardiosciences, Azienda Ospedaliera San Camillo-Forlanini, Roma, Italy;2. Division of Cardiology, Garibaldi-Nesima Hospital, Catania, Italy;3. Department of Cardiovascular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy;4. Division of Cardiology, Ospedale Monfalcone-Gorizia, Italy;5. Division of Cardiology, ASST Ovest Milanese, Legnano-Magenta, Italy;6. Division of Cardiology, S. Filippo Neri Hospital, Roma, Italy;7. Division of Cardiology, Istituti Clinici Scientifici Maugeri, IRCCS, Gattico-Veruno, Novara, Italy;8. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy;9. Department of Life, Health and Environmental Sciences, University of L''Aquila, L''Aquila, Italy |
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| Abstract: | Background and aimsAlthough hyperinsulinemia and insulin resistance (IR) together cause metabolic diseases, the available evidence fails to link hyperinsulinemia with blood pressure (BP) elevation. To further understand the role of hyperinsulinemia in the pathophysiology of hypertension, we conducted this study to investigate the moderating effect of fasting insulin (FINS) on the association between IR and BP.Methods and resultsThe health screening data of 72,076 individuals were analyzed for this moderation analysis. IR was indicated by the homeostatic model assessment of insulin resistance (HOMA-IR), triglyceride-glucose index (TyG), and triglyceride to high-density lipoprotein cholesterol ratio (TG/HDLc). In the adjusted model, three IR indicators were considered independent variables; FINS was used as a moderator, and systolic BP (SBP) and diastolic BP (DBP) were used as dependent variables. The regression coefficient of the interaction term between the three IR indicators and FINS was significantly negative in all moderation models. Simple slope tests and the Johnson–Neymann technique also indicated that FINS negatively moderated the association between IR and BP.ConclusionsThis moderation analysis showed that FINS negatively mediated the association between IR and BP, suggesting that hyperinsulinemia may buffer, not reinforce, the effect of IR on hypertension. |
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| Keywords: | Hypertension Hypertriglyceridemia Insulin resistance Moderation analysis |
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