|
|||||
|
|
Sex-specific association of BMI change with stroke in middle-aged and older adults with type 2 diabetes |
|
| Institution: | 1. China-Japan Union Hospital of Jilin University, Jilin University, China;2. School of Public Health, Capital Medical University, China;3. School of Medical and Health Sciences, Edith Cowan University, Perth, Australia;4. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, China;1. Cardiology Division of Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan;2. Chihlee Institute of Technology, New Taipei City, Taiwan;3. Department of Internal Medicine, Tri-Service General Hospital Songshan Branch, National Defense Medical Center, Taipei, Taiwan;4. Division of Nephrology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;5. Division of Cardiology, Department of Internal Medicine, Taoyuan Armed Forces General Hospital, Taoyuan County, Taiwan;6. Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan;1. Department of Systems Medicine, University of Rome Tor Vergata, Italy;2. Department of Biomedicine and Prevention, University of Rome Tor Vergata, Italy;3. Department of Surgical Science, University of Rome Tor Vergata, Italy;1. Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, China;2. Cardiovascular Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA;3. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China;4. Department of Pharmacy, The Third People''s Hospital of Changzhou, Changzhou, China;5. Department of Cardiology, The Seventh People''s Hospital of Changzhou, Changzhou, China;1. Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, China;2. Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China;3. Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, 330006, China;1. Department of Medical and Surgical Sciences, University of Bologna, Italy;2. Medical Department, Maggiore Hospital, Bologna, Italy;3. Institute of Neurological Sciences [Istituto di Ricovero e Cura a Carattere Scientifico, IRCCS], Bologna, Italy |
| Abstract: | Background and aimsWe aimed to evaluate the association between BMI change and stroke in middle-aged and older adults with type 2 diabetes and identify sex differences.Methods and resultsThe China Health and Retirement Longitudinal Study is an ongoing national population-based cohort study. Participants aged 45 or above with type 2 diabetes were enrolled and followed for stroke incidence. BMI change was defined as BMI at 2013-BMI at 2011. Of 1774 participants (mean SD] age in 2011, 60.23 8.88] years), 795 (44.8 %) were men. A total of 112 incident stroke cases were confirmed up to 2018. The incidence rate of stroke was similar between men and women (6.79 % vs 5.92 %, P = 0.516). BMI increase was independently associated with an increased stroke risk (adjusted odds ratio, 1.15; 95 % CI, 1.05–1.31) in men, while this positive association was not significant in women (adjusted odds ratio, 1.12; 95 % CI, 0.98–1.29). In addition, the positive dose–response relationship between BMI increase and stroke was observed only in men.ConclusionAmong middle-aged and older adults with type 2 diabetes, there is a sex-specific association of BMI change with stroke. An increase in BMI could result in a higher risk of incident stroke in men. |
| Keywords: | BMI change Stroke Sex difference Cohort study BMI"} {"#name":"keyword" "$":{"id":"kwrd0035"} "$$":[{"#name":"text" "_":"body mass index CHARLS"} {"#name":"keyword" "$":{"id":"kwrd0045"} "$$":[{"#name":"text" "_":"China Health and Retirement Longitudinal Study CDC"} {"#name":"keyword" "$":{"id":"kwrd0055"} "$$":[{"#name":"text" "_":"Center for Disease Control and Prevention HbA1c"} {"#name":"keyword" "$":{"id":"kwrd0065"} "$$":[{"#name":"text" "_":"glycosylated hemoglobin hs-CRP"} {"#name":"keyword" "$":{"id":"kwrd0075"} "$$":[{"#name":"text" "_":"high-sensitivity C-reactive protein eGFR"} {"#name":"keyword" "$":{"id":"kwrd0085"} "$$":[{"#name":"text" "_":"estimated glomerular filtration rate SD"} {"#name":"keyword" "$":{"id":"kwrd0095"} "$$":[{"#name":"text" "_":"standard deviation OR"} {"#name":"keyword" "$":{"id":"kwrd0105"} "$$":[{"#name":"text" "_":"odds ratio CI"} {"#name":"keyword" "$":{"id":"kwrd0115"} "$$":[{"#name":"text" "_":"confidence interval |
| 本文献已被 ScienceDirect 等数据库收录！ | |