肺癌的电镜观察

14例肺癌活检组织按照超微结构分类指标进行电镜观察。结果：鳞癌4例，腺鳞癌5例，腺癌2例，小细胞癌3例。与光镜观察诊断结果相比，两者完全相符者8例，占57％。原光镜诊为鳞癌8例，无腺鳞癌；而电镜下鳞癌4例，腺鳞癌5例，上升为35％。两者诊断的分歧明显。电镜还观察到在同一个癌细胞内出现鳞性──神经内分泌性及腺性──鳞性的双向分化。表明对癌细胞的多能分化和异质性的观察电镜优于光镜。

Electron Microscopy of Biopsies from Bronchogenic Carcinomas

Fourteen biopsy specimens from bronchogenic carcinomas were classified according to the ultrastructural features; of these, four were identified as squamous, five as adeno - squamous carcinoma, two as adeno, and three as small cell caranoma of the lung. Compared to light microscopical diagnoses based on WHO criteria, eight cases (57% ) were squamous carcinoma in accordance with the electron microscopical classincation. On light microscopy eight cases (57% ) were squamous carcinoma and no adenosquamous carcinoma was observed, but on electron microscopy four cases (28% ) were squamous and five (35% ) were adenosquamous careinoma; the discrepancy of diagnosis between LM and EM was quite apparent. On the ultrastructural level, individual cells bearing duple differentiation, squamous - neuroendocrine or adeno - squamous cells were observed. This report shows that EM is superior to LM in the exact histogenetic typing and the investigation of the multidifferentiation and heterogeneity of bronchial carcinomas.