稳定期COPD患者认知和心理状况及其相关因素分析

目的调查分析稳定期慢性阻塞性肺病(COPD)患者认知功能和心理状况及其相关影响因素.方法采用简易精神智能测定量表(MMSE)、汉密顿抑郁量表(HAMD)、汉密顿焦虑量表(HAMA)评定96例稳定期COPD患者和36例正常对照组的认知功能和心理状况,同时测定受试者FEV1%、FEV1/FVC作为肺功能指标.结果 COPD组较对照组的MMSE评分明显下降,HAMD、HAMA评分明显增高(P<0.01).COPD组抑郁发病22例(22.9%),焦虑发病28例(29.2%),抑郁焦虑共病13例(13.5%).MMSE评分与FEV1%和文化程度呈正相关,与年龄和病程呈负相关;HAMD、HAMA评分与FEV1%、文化程度和经济收入呈负相关.结论 COPD患者的认知功能下降并伴有较高的焦虑和/或抑郁症患病率.COPD患者焦虑抑郁症状与肺功能、文化程度和经济收入相关,认知功能下降与肺功能、文化程度、病程和年龄相关.

A investigation of cognitive function and emotional status and their influential factors in chronic obstructive pulmonary disease patients

Objective To investigate cognitive function, emotional status and their influential factors in chronic obstructive pulmonary disease (COPD) patients.Methods 96 COPD cases and 36 healthy persons comparable were questioned with Minimal Mental Scale Exam (MMSE), Hamilton Depression (HAMD) scale and Hamilton Anxiety (HAMA) scale respectively.Forced expiratory volume in 1 second (FEV 1) over predictive and forced vital capacity (FVC) were also measured.Results MMSE scores was significantly lower, both HAMD and HAMA scores were significantly higher in COPD group than in control (P<0.05).Of the 96 cases,22 cases (22.9%) were diagnosed as depression, 28 cases (29.2%) as anxiety and 13 cases (13.5%) as anxiety and depression.MMSE scores were correlated with FEV 1% and education degree positively; while age and period of disease, negatively.HAMD and HAMA scores were correlated with FEV 1%, education degree and income negatively.Conclusions COPD patients demonstrate high levels of depress and anxiety and low levels of cognitive function. Emotional status is correlated with FEV1%, education degree and income. Cognitive function is correlated with FEV 1%, education degree, period of disease and age.