| 琥乙红霉素胶囊处方工艺研究及溶出度测定 |
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| 引用本文： | 邓亚利,黄泓,唐继红,赵振伟.琥乙红霉素胶囊处方工艺研究及溶出度测定[J].西北药学杂志,2004,19(3):115-116. |
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| 作者姓名： | 邓亚利 黄泓 唐继红 赵振伟 |
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| 作者单位： | 1. 陕西东盛医药有限责任公司,陕西,西安,710075
2. 陕西省西安制药厂,陕西,西安,710077 |
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| 摘 要： | 目的 琥乙红霉素胶囊处方筛选及溶出度测定。方法 通过正交试验筛选出胶囊剂的处方 ,采用硫酸比色法测定其溶出度。结果 最佳处方为 5 0 g·L-1的 CMC- Na、5 g交联 PVP、0 .5 g十二烷基硫酸钠、0 .5 g蔗糖酯 ;胶囊 30 min时溶出度大于 80 %。结论 组方合理 ,制备工艺简便易行 ,溶出度可控
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| 关 键 词： | 琥乙红霉素 正交试验 溶出度 |
| 文章编号： | 1004-2407(2004)03-0115-02 |
| 修稿时间： | 2003年9月16日 |
Investigation on formulation process and dissolution determination of erythromycin ethylsuccinate |
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| DENG Ya-li ,HUANG Hong ,TANG Ji-hong ,ZHAO Zhen-wei.Investigation on formulation process and dissolution determination of erythromycin ethylsuccinate[J].Northwest Pharmaceutical Journal,2004,19(3):115-116. |
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| Authors: | DENG Ya-li HUANG Hong TANG Ji-hong ZHAO Zhen-wei |
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| Institution: | DENG Ya-li 1,HUANG Hong 2,TANG Ji-hong 2,ZHAO Zhen-wei 2 |
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| Abstract: | Objective To investigate the formulation process and dissolution determination of erythromycin ethylsuccinate. Methods The formulation was optimized by orthogonal test. The dissolution was determinated by sulfuric acid colorimetric method. Results The optimal formulation was as following: 50 g·L -1 CMC-Na, 5 g PVPP, 0.5 g SDS and 0.5 g Sugar Ester. The dissolution of Capsule was no less than 80% after 30 minutes. Conclusion The formulation is reasonable, convenient and the dissolution method is suitable for quality control. |
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| Keywords: | Erythromycin Ethylsuccinate orthogonal test dissolution |
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