Assessment of genotoxic and mutagenic potential of hexavalent chromium in the freshwater fish Labeo rohita (Hamilton, 1822) |
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| Authors: | Naresh Sahebrao Nagpure Rashmi Srivastava Basdeo Kushwaha Satish Kumar Srivastava Pavan Kumar |
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| Affiliation: | Molecular Biology and Biotechnology Division, National Bureau of Fish Genetic Resources, Lucknow, U. P., India |
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| Abstract: | The present study was undertaken to investigate the genotoxicity and mutagenicity of sublethal concentrations of hexavalent chromium (potassium dichromate) in the Indian major carp, Labeo rohita. The 96?h LC50 value of potassium dichromate estimated was 118?mg?L?1 by probit analysis using SPSS (version 16.0) software. Based on 96?h LC50 value, three sublethal test concentrations of potassium dichromate (29.5, 59.0 and 88.5?mg?L?1) were selected and specimens were exposed in vivo to these test concentrations for 96?h. The mutagenic and genotoxic effects of potassium dichromate were evaluated in gill and blood cells using micronucleus (MN) test and comet assay. In general, significant (p?
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| Keywords: | Acute toxicity genotoxicity hexavalent chromium Labeo rohita mutagenicity |
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