Role of CT-guided percutaneous lung biopsy in diagnosis of pulmonary fungal infection in patients with hematologic diseases |
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Authors: | Ji-Min Shi Zhen Cai He Huang Xiu-Jin Ye Jing-Song He Wan-Zhuo Xie Jie Zhang Xian-Yong Zhou Yi Luo Yu Lin Li Li Wei-Yan Zheng Guo-Qing Wei Mao-Fang Lin |
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Institution: | (1) The Center of Hematology and Bone Marrow Transplantation, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;(2) Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University Medical College, 79 Qingchun Road, 310003 Hangzhou, Zhejiang, People’s Republic of China |
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Abstract: | The goal of our study is to evaluate the efficiency and safety of CT-guided percutaneous lung biopsy for the diagnosis of
pulmonary fungal infection in patients with hematologic disease. Medical records were retrospectively reviewed for 16 patients
with hematologic diseases, who were initially suspected to have pulmonary fungal infection clinically and underwent further
diagnostic methods including blood culture, sputum culture and percutaneous lung biopsy. Of the 16 patients, 10 were diagnosed
fungal infection (8 aspergillus, 2 mold fungus), 4 chronic organizing pneumonitis, 1 tuberculosis, and 1 Pneumocystis carinii
through histological examination after percutaneous lung biopsy. However, the results of blood culture and sputum culture
were negative. CT-guided biopsy showed 100% overall accuracy and 62.5% (10/16) fungal infection rate. The biopsy-induced complications
encountered were pneumothorax in 3/16 (18.75%) and hemoptysis in 1/16 (6.25%). No serious complication was found in this series.
In conclusion, CT-guided percutaneous lung biopsy is an effective and safe method for the diagnosis of pulmonary fungal infection
in patients with hematologic diseases. |
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Keywords: | CT Percutaneous lung biopsy Hematologic diseases Fungal infection Diagnosis |
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