| 结直肠癌非随机性染色体异常的研究 |
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| 引用本文： | 李立,严律南,吴言涛,汪林,周宏远.结直肠癌非随机性染色体异常的研究[J].中国普外基础与临床杂志,1996(4). |
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| 作者姓名： | 李立 严律南 吴言涛 汪林 周宏远 |
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| 作者单位： | 华西医科大学附属第一医院普外科，北京医科大学附一院内科，华西医科大学肿瘤研究所 |
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| 摘 要： | 对１８例结直肠癌患者采用实体瘤短期体外悬浮细胞培养法进行染色体分析。结果：染色体结构重排涉及１７ｑ、５ｑ、６ｑ（７８％、６１％、５０％），染色体增加频率最高的是７号、３号（７２％、６６％），丢失则最常见于１７号、５号、１８号（５０％、４４％、３３％）。大量标记染色体、双微体及超倍体核型预示肿瘤易早期复发和转移。此结果提示：１７号、５号及１８号染色体畸变与结直肠癌发生发展有密切关系。非随机性染色体异常的多样性和复杂性更表明大肠癌的发生是多基因多步骤演变的结果。
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| 关 键 词： | 结直肠癌，细胞遗传，染色体，预后 |
A STUDY OF CHROMOSOMAL ABNORMALITY IN COLORECTAL CARCINOMA |
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| Li Li,Yan Lunan,Wu Yantao,et al..A STUDY OF CHROMOSOMAL ABNORMALITY IN COLORECTAL CARCINOMA[J].Chinese Journal of Bases and Clinics In General Surgery,1996(4). |
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| Authors: | Li Li Yan Lunan Wu Yantao |
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| Abstract: | Cytogenetic study of 18 colorectal carcinomas confirmed the extensive heterogeneity and the complexity of the karyotypic picture in this tumror.Karyotypic analysis showed that chromosomes 7 and 3 were of the highest chromosomal gaining frequencies (72%,66% )and chromosomal losses were shown in chromosome 17 (50%),chromosome 5 (44%)and chromosome 18 (33%).The structural rearrangements frequently involved were 17p(78 %),5q(61 %),6q,7q,8p,12q, 2p, etc. A great number of marker chromosomes and polyploid chromosomes had bad prognosis relatively. According to these results,we conclude that chromosomes 17, 5,and 18 may play an important role in the evolution of colorectal cancer. |
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| Keywords: | Colorectal cancer Cytogenet Chromosome Prognosis |
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