Roles of the CXCR1/CXCL8 axis in abnormal proliferation of bile duct epithelial cells in primary biliary cholangitis

<正>Objective To investigate the role of the CXC chemokine receptor 1(CXCR1)/CXC chemokine ligand8(CXCL8) axis in the abnormal proliferation of bile duct epithelial cells in primary biliary cholangitis(PBC).Methods 30 female C57BL/6 mice were randomly divided into the PBC model group(PBC group),reparixin intervention group(Rep group),and blank control group(Con group) in an in vivo experiment.PBC animal models were established after 12weeks of intraperitoneal injection of 2-octanoic acid co...